Dr. Behçet Uz Children's Hospital, Department of Pediatric Infectious Diseases, İzmir, Turkey.
Dr. Behçet Uz Children's Hospital, Department of Pediatric Infectious Diseases, İzmir, Turkey.
J Clin Virol. 2020 Jul;128:104355. doi: 10.1016/j.jcv.2020.104355. Epub 2020 Apr 18.
The influenza virus is a significant cause of acute lower respiratory tract infections (LRTI) requiring hospitalization in childhood and leads to severe morbidity and mortality, especially in certain risk groups.
The study aims to evaluate acute LRTI due to influenza in a tertiary care hospital and the risk factors for hospitalization among Turkish children.
Children between 1 month and 18 years of age who were hospitalized at Dr. Behçet Uz Children's Hospital between January 2016 and March 2018 with lower respiratory tract infection that tested positive for influenza by PCR were included. Children with viral coinfections were excluded. Patient files were retrospectively scanned from the hospital computerized system in terms of age, underlying diseases, whether antiviral therapy was used, and length of hospital stay. Statistical analysis was performed using SPSS statistical software.
The study included 131 patients with a median age of 2 years (1 month-15 years). Sixty-seven (51,1%) patients were younger than two years. Influenza A was isolated in 129 patients and B in 2 patients. Fifty-two patients (39,7%) had underlying medical conditions, and the most common one was malignancies (12/52, 23%). This was followed by neurodevelopmental diseases (9/52, 17,3%), prematurity (9/52 patients, 17,3%), primary immunodeficiency (8/52, 15,4%), asthma (7/52, 13,4%), Down syndrome (4/52, 7,7%), chronic renal disease (2/52, 3,8%) and congenital heart diseases (1/52, 1,9%). The mean length of stay (LOS) was 12,3 ± 9,5 days (2-60 days). The LOS was found to be statistically longer (15,2 ± 12,1 days, 3-60 days) in patients with an underlying disease compared to previously healthy patients (10,4 ± 6,7 days, 2-35 days) (p = 0.01).
Hospitalization due to influenza-related acute LRTI is not an issue only for patients with an underlying medical condition. Vaccination should be considered not only for those with underlying medical conditions but also for healthy children.
流感病毒是导致儿童急性下呼吸道感染（LRTI）需要住院的重要原因，可导致严重的发病率和死亡率，尤其是在某些高危人群中。
本研究旨在评估在一家三级保健医院中因流感导致的急性 LRTI 以及土耳其儿童住院的危险因素。
本研究纳入了 2016 年 1 月至 2018 年 3 月期间在 Dr. Behçet Uz 儿童医院因呼吸道感染而住院且 PCR 检测流感病毒阳性的 1 个月至 18 岁儿童。排除了病毒合并感染的患儿。从医院计算机系统中回顾性扫描患儿的病历，记录年龄、基础疾病、是否使用抗病毒治疗以及住院时间。使用 SPSS 统计软件进行统计学分析。
本研究共纳入了 131 例患儿，中位年龄为 2 岁（1 个月-15 岁）。67 例（51.1%）患儿年龄小于 2 岁。129 例患儿分离出甲型流感病毒，2 例分离出乙型流感病毒。52 例（39.7%）患儿存在基础疾病，最常见的疾病为恶性肿瘤（12/52，23%）。其次为神经发育疾病（9/52，17.3%）、早产（9/52 例，17.3%）、原发性免疫缺陷（8/52，15.4%）、哮喘（7/52，13.4%）、唐氏综合征（4/52，7.7%）、慢性肾脏疾病（2/52，3.8%）和先天性心脏病（1/52，1.9%）。平均住院时间（LOS）为 12.3 ± 9.5 天（2-60 天）。与无基础疾病的患儿相比，存在基础疾病的患儿的 LOS 明显更长（15.2 ± 12.1 天，3-60 天）（p = 0.01）。
流感相关急性 LRTI 导致的住院不仅是有基础疾病的患儿面临的问题。不仅应考虑为有基础疾病的患儿接种疫苗，还应考虑为健康儿童接种疫苗。
