York K K, Miller S, Gaster R N, Burstein N L
Department of Ophthalmology, California College of Medicine, University of California, Irvine.
J Ocul Pharmacol. 1988 Winter;4(4):351-8. doi: 10.1089/jop.1988.4.351.
Polyvinylpyrrolidone-iodine (PVP-I) is a biocompatible broad spectrum antimicrobial that is widely used as an ophthalmic pre-operative prepping agent. In order to determine if PVP-I is safe for treating corneal ulcers and conjunctivitis, we evaluated the ocular toxicity of frequent dosing in a rabbit model. We evaluated ocular irritation in 18 rabbits according to the McDonald-Shadduck method. Concentrations of 0.5% PVP-I or less were practically non-irritating when administered six times per day. We evaluated corneal epithelial wound healing in 16 rabbits with standardized abrasions. Concentrations of 0.33% PVP-I showed epithelial healing comparable to gentamicin treated eyes and untreated controls. Concentrations of 0.5% PVP-I delayed epithelial healing by one day. Because of its broad spectrum and apparently low toxicity, PVP-I may be a useful treatment for corneal ulcers, keratitis and conjunctivitis.
聚维酮碘（PVP - I）是一种具有生物相容性的广谱抗菌剂，被广泛用作眼科术前准备剂。为了确定PVP - I治疗角膜溃疡和结膜炎是否安全，我们在兔模型中评估了频繁给药的眼毒性。我们根据麦克唐纳 - 沙德达克方法评估了18只兔子的眼刺激情况。当每天给药6次时，0.5%及以下浓度的PVP - I几乎无刺激性。我们评估了16只经标准化擦伤的兔子的角膜上皮伤口愈合情况。0.33%浓度的PVP - I显示上皮愈合情况与庆大霉素治疗的眼睛及未治疗的对照组相当。0.5%浓度的PVP - I使上皮愈合延迟了一天。由于其广谱性和明显较低的毒性，PVP - I可能是治疗角膜溃疡、角膜炎和结膜炎的有效药物。
