Nelson J D, Silverman V, Lima P H, Beckman G
Department of Ophthalmology, St. Paul-Ramsey Medical Center, MN.
Curr Eye Res. 1990 Mar;9(3):277-85. doi: 10.3109/02713689009044524.
The effects of gentamicin, tobramycin and the fluorquinolone, ofloxacin on corneal epithelial wound healing were determined using an in vitro model of wound healing. Wounds were created in rabbit corneal epithelial cultures which were then exposed to various concentrations of the antibiotics. Effects on wound healing were measured by comparing migration rates between 6 and 18 hours and wound areas at various antibiotic concentrations over 36 hours. Gentamicin at concentrations of 0.5, 1.0, 1.5 and 2.0 mg/ml was found to statistically significantly effect wound healing compared to controls. Tobramycin on the other hand was found to have minimal effect on wound healing up to 2.0 mg/ml. Ofloxacin at concentrations greater than or equal to 0.05 mg/ml had statistically significant effects on wound-healing.
使用伤口愈合的体外模型，测定庆大霉素、妥布霉素和氟喹诺酮类药物氧氟沙星对角膜上皮伤口愈合的影响。在兔角膜上皮培养物中制造伤口，然后将其暴露于不同浓度的抗生素中。通过比较6至18小时之间的迁移率以及36小时内不同抗生素浓度下的伤口面积，来测量对伤口愈合的影响。发现浓度为0.5、1.0、1.5和2.0mg/ml的庆大霉素与对照组相比，对伤口愈合有统计学上的显著影响。另一方面，发现高达2.0mg/ml的妥布霉素对伤口愈合的影响极小。浓度大于或等于0.05mg/ml的氧氟沙星对伤口愈合有统计学上的显著影响。
