Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Int J Environ Res Public Health. 2020 May 26;17(11):3760. doi: 10.3390/ijerph17113760.
The efficacy of exercise to reverse frailty in the aging population has not been extensively investigated. This study aimed to investigate the effectiveness of a multicomponent exercise program (MCEP) on frailty, physical performance (handgrip strength, Berg Balance Scale (BBS), Timed Up and Go test (TUG), and VOMax), blood biomarkers (Interleukin-6 (IL-6) and C-reactive protein (CRP)) in frail older adults. A randomized controlled trial using an allocation concealment method, included 64 older adults (77.78 ± 7.24 years), were divided into two parallel groups using block randomization: an MCEP group ( = 32) and a control group ( = 32). The combined center- and home-based MCEP training consisted of chair aerobic, resistance, and balance, which was carried out 3 days per week for 24 weeks. A mixed model repeated measure ANOVA demonstrated significant interaction effects of group x time for BBS, TUG and frailty scores ( < 0.001). Additionally, the post-hoc analysis revealed that the MCEP group showed significantly improved BBS, TUG, and frailty scores ( < 0.01), at both 12- and 24-weeks. When compared with controls at 12-weeks, the MCEP group decreased IL-6 and CRP levels ( < 0.05). The combined center- and home-based MCEP were effective in reversing frailty to pre-frailty and improving physical performance especially balance in the older population.
运动对衰老人群虚弱的逆转效果尚未得到广泛研究。本研究旨在调查多组分运动方案（MCEP）对虚弱、身体表现（握力、伯格平衡量表（BBS）、计时起立行走测试（TUG）和最大摄氧量（VOMax））、血液生物标志物（白细胞介素-6（IL-6）和 C 反应蛋白（CRP））的有效性。采用分配隐藏方法的随机对照试验，纳入 64 名年龄在 77.78 ± 7.24 岁的虚弱老年人，采用区组随机分组法分为两组：MCEP 组（n = 32）和对照组（n = 32）。综合中心和家庭的 MCEP 训练包括椅子有氧运动、阻力和平衡训练，每周进行 3 天，共 24 周。混合模型重复测量方差分析显示 BBS、TUG 和虚弱评分的组 x 时间存在显著交互作用（<0.001）。此外，事后分析显示 MCEP 组的 BBS、TUG 和虚弱评分显著改善（<0.01），在 12 周和 24 周时均如此。与 12 周时的对照组相比，MCEP 组的 IL-6 和 CRP 水平降低（<0.05）。综合中心和家庭的 MCEP 对将虚弱逆转至虚弱前期和改善老年人的身体表现，特别是平衡能力，非常有效。
