Dalmartello Michela, Negri Eva, La Vecchia Carlo, Scarfone Giovanna, Buonomo Barbara, Peccatori Fedro A, Parazzini Fabio
Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Department of Clinical and Biological Sciences, University of Milan, 20122 Milan, Italy.
Cancers (Basel). 2020 May 26;12(6):1356. doi: 10.3390/cancers12061356.
Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference population. We conducted a systematic review of population-based studies on PAC published up to December 2019, to provide updated research on this topic, highlighting strengths and limitations. Of the 24 papers included, 11 considered all types of tumors and 13 dealt with specific types of cancer. Differences in the procedures for estimating the frequency of PAC emerged even among population studies. However, we found consistent results for overall frequency of PAC- around 1/1000 pregnancies. Our review suggests that about 25% of PAC cases are diagnosed during pregnancy, confirming the hypothesis of an excess of diagnosis in the postpregnancy period. Sparse and inconsistent results were found regarding a potential increase in the frequency of PAC over calendar years. Alignments in the strategy to identify PAC are needed to overcome methodological weaknesses.
尽管有大量可用的证据资源，但由于研究设计和方法、纳入标准、随访时间不一致以及参考人群的异质性，关于妊娠相关癌症（PAC）发生率的结果仍显示出较差的可比性。我们对截至2019年12月发表的关于PAC的基于人群的研究进行了系统综述，以提供关于该主题的最新研究，突出优点和局限性。在纳入的24篇论文中，11篇考虑了所有类型的肿瘤，13篇涉及特定类型的癌症。即使在人群研究中，估计PAC发生率的程序也存在差异。然而，我们发现PAC总体发生率的结果是一致的——约为每1000次妊娠中有1例。我们的综述表明，约25%的PAC病例在孕期被诊断出来，证实了产后诊断过多的假设。关于PAC发生率在历年中是否可能增加，研究结果稀少且不一致。需要在识别PAC的策略上保持一致，以克服方法上的弱点。
