Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio.
Retina. 2021 Mar 1;41(3):602-609. doi: 10.1097/IAE.0000000000002864.
To assess the visualization of choroidal granulomas with swept-source optical coherence tomography angiography (OCTA).
Consecutive patients with granulomatous choroiditis due to tuberculosis, sarcoidosis, or Vogt-Koyanagi-Harada disease underwent baseline OCTA images using a 12 × 12-mm field of view, and the choroidal slabs were analyzed by two independent examiners who counted the oval areas of flow void. Simultaneously, indocyanine green angiography (ICGA) and enhanced-depth imaging OCT were performed to mark visible choroidal changes corresponding to granulomatous lesions. The lesion areas on OCTA and ICGA were assessed using the in-built caliper tool.
Three hundred and one round-shaped areas of flow void on OCTA, 209 hypofluorescent round lesions on ICGA, and 42 hyporeflective choroidal lesions on enhanced-depth imaging OCT were identified in 23 eyes from 14 patients. Of the 209 ICGA granulomas, 197 (94.3%) had a corresponding round area of flow void on OCTA that was interpreted as a granuloma. One hundred and four additional round flow voids were identified on OCTA that did not correspond to any hypofluorescent lesion on ICGA. The mean area of the 197 granulomas detected with both imaging modalities was significantly larger on ICGA (mean 0.33 mm2) than that on OCTA (mean 0.28 mm2).
Optical coherence tomography angiography seems to be an optimal imaging method for the visualization of choroidal granulomas.
评估扫频源光相干断层扫描血管造影（OCTA）对脉络膜肉芽肿的可视化效果。
连续纳入结核、结节病或 Vogt-Koyanagi-Harada 病引起的肉芽肿性脉络膜炎患者，使用 12×12mm 视野进行基线 OCTA 成像，两名独立的检查者分析脉络膜切片，计算椭圆形无血流区域的数量。同时，进行吲哚菁绿血管造影（ICGA）和增强深度成像 OCT 以标记与肉芽肿病变相对应的可见脉络膜变化。使用内置卡尺工具评估 OCTA 和 ICGA 上的病变区域。
在 14 名患者的 23 只眼中，共发现 301 个 OCTA 上的圆形无血流区域、209 个 ICGA 上的低荧光圆形病变和 42 个增强深度成像 OCT 上的低反射性脉络膜病变。在 209 个 ICGA 肉芽肿中，197（94.3%）个在 OCTA 上有对应的圆形无血流区域，被解释为肉芽肿。OCTA 上还发现了 104 个额外的圆形无血流区域，与 ICGA 上任何低荧光病变均不对应。两种成像方式均检测到的 197 个肉芽肿的平均面积在 ICGA 上（平均 0.33mm2）显著大于 OCTA 上（平均 0.28mm2）。
OCTA 似乎是可视化脉络膜肉芽肿的最佳成像方法。
