Pancar Gunseli Sefika, Kalkan Goknur, Eyupoglu Oznur
Department of Dermatology, Samsun Government Hospital, Samsun, Turkey.
Department of Dermatology, School of Medicine, Yildirim Beyazit University, Ankara, Turkey.
Postepy Dermatol Alergol. 2020 Feb;37(1):29-33. doi: 10.5114/ada.2020.93381. Epub 2020 Mar 9.
The alexandrite laser (AL) is a very safe and effective treatment used for unwanted hair removal with a reported success rate of 40% to 80% at 6 months and after several treatment sessions. Although a diffuse variety of side effects has been observed during laser treatment, changes in skin dryness and pruritus before and after AL epilation have not been reported yet to the best of our knowledge.
To investigate the effects of 755 nm alexandrite laser on skin dryness and pruritus at the beginning and in the third and the sixth month after the treatment.
Forty three patients with Fitzpatrick skin types of II-IV aged 18-45 with leg hair were included in this prospective study. Patients were treated with 755 nm alexandrite laser with 10-12 mm spot size. According to the skin phototype, the settings of the laser were as follows: 12-22 J/cm² and pulse width of 3 ms. For self-assessment by the patient, the visual analogue scale (VAS) was used before, at the third and sixth month of the treatment as to skin dryness and pruritus. The patients were evaluated by the same dermatologist with the same VAS. The values were compared between before-at the third month, before-at the sixth month and at the third and at the sixth month of the treatment.
Pruritus scores were statistically lower at the third month when compared with the baseline scores ( < 0.01). However, there was no difference between the third and sixth month of the treatment as to pruritus scores ( > 0.05). There was a statistically significant difference between the scores before the treatment and the scores at the third month and at the sixth month as to skin dryness ( < 0.001). However, the difference was not prominent between the third and sixth month scores of skin dryness ( > 0.05).
To the best of our knowledge, this is the first study researching the effects of AL on pruritus and skin dryness. Further studies with larger samples and longer follow-up periods will be able to better clarify the association.
翠绿宝石激光（AL）是一种用于去除多余毛发的非常安全有效的治疗方法，据报道，经过几次治疗后，6个月时的成功率为40%至80%。尽管在激光治疗过程中观察到了各种各样的副作用，但就我们所知，尚未有关于翠绿宝石激光脱毛前后皮肤干燥和瘙痒变化的报道。
研究755nm翠绿宝石激光治疗开始时以及治疗后第三个月和第六个月对皮肤干燥和瘙痒的影响。
本前瞻性研究纳入了43例年龄在18 - 45岁、Fitzpatrick皮肤类型为II - IV型且腿部有毛发的患者。患者接受光斑大小为10 - 12mm的755nm翠绿宝石激光治疗。根据皮肤光型，激光设置如下：能量密度为12 - 22J/cm²，脉宽为3ms。为了让患者进行自我评估，在治疗前、治疗第三个月和第六个月使用视觉模拟量表（VAS）评估皮肤干燥和瘙痒情况。由同一位皮肤科医生使用相同的VAS对患者进行评估。比较治疗前与第三个月、治疗前与第六个月以及治疗第三个月和第六个月之间的数值。
与基线评分相比，第三个月时瘙痒评分在统计学上更低（<0.01）。然而，治疗第三个月和第六个月之间的瘙痒评分没有差异（>0.05）。治疗前与第三个月以及第六个月的皮肤干燥评分在统计学上有显著差异（<0.001）。然而，第三个月和第六个月的皮肤干燥评分之间的差异不显著（>0.05）。
据我们所知，这是第一项研究翠绿宝石激光对瘙痒和皮肤干燥影响的研究。进一步开展更大样本量和更长随访期的研究将能够更好地阐明这种关联。
