Kenawy Mohamed Zaki, Sabry Jehan Hasan, Akl Essam Mohamed, Emam Noha A H
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, BenhaUniversity, Benha, Egypt.
Department of Clinical Pathology, Faculty of Medicine, BenhaUniversity, Benha, Egypt.
Postepy Dermatol Alergol. 2020 Feb;37(1):86-91. doi: 10.5114/ada.2018.79225. Epub 2020 Mar 9.
Psoriasis is a chronic disease of inflammatory nature which can be considered as a systemic disorder. Metabolic syndrome is prevalent in psoriatic patients, with a negative impact on disease severity. Angiopoietin-like protein 2 (ANGPTL2) role has been investigated in several chronic inflammatory conditions, but not in psoriasis.
To evaluate the serum level of ANGPTL2 and its possible role in the occurrence of metabolic syndrome in psoriatic patients.
This study enrolled 180 participants divided into two groups: psoriatic group (120 patients with chronic plaque psoriasis) and control group (60 normal subjects). Psoriasis severity was determined by the psoriasis area severity index. Anthropometric measurements, lipid profile, fasting blood sugar and ANGPTL2 have been evaluated in both groups.
Psoriatic patients had a higher body mass index ( = 0.014), waist circumference ( < 0.001), and blood pressure than controls ( Ł 0.001). Fasting blood sugar and the serum level of ANGPTL2 were also higher in psoriatic patients than in controls ( < 0.001, 0.025, respectively). In addition, the serum level of ANGPTL2 was significantly correlated with both disease severity ( < 0.001) and occurrence of metabolic syndrome ( < 0.001).
Serum ANGPTL2 is elevated in psoriasis patients compared to normal subjects. Serum ANGPTL2 elevation may have a role in chronic inflammatory status in psoriasis and occurrence of metabolic syndrome.
银屑病是一种具有炎症性质的慢性疾病，可被视为一种全身性疾病。代谢综合征在银屑病患者中普遍存在，对疾病严重程度有负面影响。血管生成素样蛋白2（ANGPTL2）在几种慢性炎症性疾病中的作用已得到研究，但在银屑病中尚未研究。
评估银屑病患者血清ANGPTL2水平及其在代谢综合征发生中的可能作用。
本研究纳入180名参与者，分为两组：银屑病组（120例慢性斑块状银屑病患者）和对照组（60名正常受试者）。通过银屑病面积严重指数确定银屑病严重程度。对两组患者均进行了人体测量、血脂谱、空腹血糖和ANGPTL2评估。
银屑病患者的体重指数（ = 0.014）、腰围（ < 0.001）和血压均高于对照组（ Ł 0.001）。银屑病患者的空腹血糖和血清ANGPTL2水平也高于对照组（分别为 < 0.001，0.025）。此外，血清ANGPTL2水平与疾病严重程度（ < 0.001）和代谢综合征的发生（ < 0.001）均显著相关。
与正常受试者相比，银屑病患者血清ANGPTL2升高。血清ANGPTL2升高可能在银屑病的慢性炎症状态和代谢综合征的发生中起作用。
