St. Vincent's University Hospital, Dublin, Ireland.
Int J Dermatol. 2017 Nov;56(11):1103-1118. doi: 10.1111/ijd.13699. Epub 2017 Aug 1.
Adipokines are secreted by white adipose tissue, an active endocrine organ, and play a role in the regulation of metabolic functions such as lipid metabolism, inflammation, and vascular homeostasis. Adipokines are secreted in excess in obesity and contribute to the development of associated comorbidities such as metabolic syndrome and atherosclerosis. Psoriasis, a chronic immune-mediated skin disease, is associated with obesity and increased cardiovascular risk. Understanding the role of adipokines in psoriasis may in part explain the association between psoriasis and cardiovascular disease. This review summarizes the data regarding key adipokines in patients with psoriasis and the change in adipokine profiles with psoriasis therapy. Adipokines may be mediators of cutaneous inflammation suggesting a role in the pathophysiology of psoriasis and the development of comorbidities.
脂肪细胞因子由白色脂肪组织分泌，白色脂肪组织是一种活跃的内分泌器官，在调节脂质代谢、炎症和血管稳态等代谢功能方面发挥作用。脂肪细胞因子在肥胖中过度分泌，并导致代谢综合征和动脉粥样硬化等相关合并症的发展。银屑病是一种慢性免疫介导的皮肤病，与肥胖和心血管风险增加有关。了解脂肪细胞因子在银屑病中的作用可能部分解释了银屑病与心血管疾病之间的关联。本文综述了银屑病患者中关键脂肪细胞因子的数据以及银屑病治疗过程中脂肪细胞因子谱的变化。脂肪细胞因子可能是皮肤炎症的介质，提示其在银屑病的病理生理学和合并症的发展中发挥作用。
