Zong Xing-Xing, Wang Yu, Xiong Jia-Liang, Ping Yu-Hui, Liang Qiong-Lin
Department of Chemistry, Tsinghua University, Beijing, PR China.
Department of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Nat Prod Res. 2022 Jan;36(1):429-431. doi: 10.1080/14786419.2020.1771712. Epub 2020 May 29.
is widely used as traditional Chinese medicine for treating the swelling of the gums and tongue and mouth sores due to flame stomach fire. It is mainly origin from Guangxi, Sichuan provinces of China. Alkaloids are considered as the major bioactive components. A method was established for identifying alkaloids in root by UPLC-Q-TOF-MS/MS and was applied in characterizing alkaloids in root of two different habitats. Consequently, twenty-four alkaloids including six new compounds were identified in root. Additionally, the difference of alkaloids in from Guozhou, Sichuan province was investigated. In the present study, we firstly characterize total alkaloids in root by UPLC-Q-TOF-MS/MS and firstly established the characteristic fragmentation pathway of alkaloids with hydroxy in root.
作为传统中药被广泛用于治疗因胃火上炎引起的牙龈肿痛、口舌生疮。其主要来源于中国广西、四川等地。生物碱被认为是主要的生物活性成分。建立了一种通过超高效液相色谱-四极杆飞行时间串联质谱（UPLC-Q-TOF-MS/MS）鉴定其根中生物碱的方法，并应用于表征两种不同产地根中的生物碱。结果，在其根中鉴定出24种生物碱，包括6种新化合物。此外，还研究了四川泸州的其生物碱差异。在本研究中，我们首先通过UPLC-Q-TOF-MS/MS表征其根中的总生物碱，并首次建立了其根中含羟基生物碱的特征性裂解途径。
