Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
Physiol Res. 2020 Jul 16;69(3):515-520. doi: 10.33549/physiolres.934242. Epub 2020 May 29.
Obesity is a disease that affects about 13 % of the world population (2016) (Who 2018). This condition generates a process of systemic inflammation that may contribute to the release of cell-free DNA (cfDNA) into the bloodstream. cfDNA has been considered a potential biomarker to monitor several physiological and pathological conditions, such as tumors, exercise intensity and obesity. Therefore, the objective of this study was to evaluate the association of cfDNA levels with the amount of weight and fat mass lost six months after bariatric surgery. Thirty-eight subjects classified as obese (BMI, 43.5+/-6.2; BFP, 46.6+/-4.8) were evaluated anthropometrically and underwent bariatric surgery. Weight, BMI, body fat percentage (BFP), waist circumference, C-Reactive Protein (CRP) and cfDNA levels were evaluated before and six months after surgery; furthermore, a correlation was performed between cfDNA levels and BFP and CRP. Decrease in total body weight and CRP were observed after bariatric surgery; however, the cfDNA levels remained unchanged. There was a weak correlation between cfDNA levels and BFP before the bariatric surgery, and a moderate correlation between cfDNA and CRP. Obese subjects who underwent bariatric surgery, the decrease in body fat percentage did not result in changes in cfDNA levels six months after surgery.
肥胖是一种影响约 13%世界人口（2016 年）（世界卫生组织 2018 年）的疾病。这种情况会导致全身炎症过程，这可能导致游离细胞 DNA（cfDNA）释放到血液中。cfDNA 已被认为是监测多种生理和病理状况（如肿瘤、运动强度和肥胖）的潜在生物标志物。因此，本研究的目的是评估 cfDNA 水平与减肥手术后 6 个月体重和体脂量的关系。38 名肥胖受试者（BMI，43.5+/-6.2；BFP，46.6+/-4.8）进行了人体测量学评估，并接受了减肥手术。在手术前和手术后 6 个月评估体重、BMI、体脂百分比（BFP）、腰围、C-反应蛋白（CRP）和 cfDNA 水平；此外，还对 cfDNA 水平与 BFP 和 CRP 之间进行了相关性分析。减肥手术后体重和 CRP 均下降；然而，cfDNA 水平保持不变。减肥手术前 cfDNA 水平与 BFP 之间存在弱相关性，cfDNA 与 CRP 之间存在中度相关性。接受减肥手术的肥胖受试者，体脂百分比的下降并未导致手术后 6 个月 cfDNA 水平的变化。
