Naranjo Andrea, Martinez Jaime D, Miller Darlene, Tonk Rahul, Amescua Guillermo
Anne Bates Leach Eye Clinics, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ocul Immunol Inflamm. 2021 Nov 17;29(7-8):1576-1584. doi: 10.1080/09273948.2020.1758156. Epub 2020 May 29.
: To report our experience with oral miltefosine (MLT) as an adjunct treatment for progressive keratitis (AK).: Retrospective case series of all patients who underwent treatment with oral MLT for AK at Bascom Palmer Eye Institute from 2017 to 2020.: Six females from 16 to 55 years old, with a microbiologic diagnosis of , were treated with MLT and standard medical treatment. Four of the six cases deteriorated after initiating treatment and three required a therapeutic keratoplasty. Two patients improved after 1 week of MLT and optical penetrating keratoplasty was performed after clinical resolution. Microbiologic culture of corneal buttons was negative in all cases. All corneal grafts remain clear at last follow-up with best-corrected visual acuity of 20/40 or better.: Oral MLT may be a viable adjunctive therapy for recalcitrant AK; however, its use may be associated with a severe inflammatory reaction. Further studies are needed to evaluate its efficacy and variable clinical response.
报告我们使用口服米替福新（MLT）作为进行性角巩膜炎（AK）辅助治疗的经验。
对2017年至2020年在巴斯科姆·帕尔默眼科研究所接受口服MLT治疗AK的所有患者进行回顾性病例系列研究。
6名年龄在16至55岁的女性，微生物学诊断为……，接受了MLT和标准药物治疗。6例中有4例在开始治疗后病情恶化，3例需要进行治疗性角膜移植术。2例患者在MLT治疗1周后病情改善，临床症状消退后进行了光学穿透性角膜移植术。所有病例的角膜植片微生物培养均为阴性。在最后一次随访时，所有角膜移植片均保持清晰，最佳矫正视力为20/40或更好。
口服MLT可能是顽固性AK的一种可行辅助治疗方法；然而，其使用可能与严重的炎症反应有关。需要进一步研究来评估其疗效和不同的临床反应。
