Bagga Bhupesh, Gowtham Lakshminarayanan, Ahirwar Lalit Kishore, Sen Debkuntal, Jakati Saumya, Ali Md Hasnat, Sharma Savitri
The Ramoji Foundation Centre for Ocular infection, Shantilal Shanghvi Cornea Institute, Hyderabad, India.
Dr. Chigurupati Nageshwara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India.
J Ophthalmic Inflamm Infect. 2025 Mar 5;15(1):18. doi: 10.1186/s12348-025-00466-w.
To report the outcome of Acanthamoeba keratitis, with early addition of Photo-dynamic antimicrobial therapy with Rose Bengal (PDAT-RB) to the medical treatment (combination of 0.02% Polyhexamethylene Biguanide (PH)and 0.02% chlorhexidine(CH)).
Patients were recruited based on the infiltrate size being < 8 mm and limited to the mid stroma, < 300µ, and confirmed microbiological diagnosis. Along with the continuation of PHMB + CH, patients were also treated with PDAT-RB twice with a gap of one week using 0.1% w/v RB and green LED (525 nm) array immediately after the confirmation of diagnosis.
A total of 14 patients were enrolled. All the enrolled patients received adjuvant PDAT-RB within 5 (2.5 to 11) days of diagnosis. The average diameter and median depth of the infiltrate were 5.7 ± 1.56(V), 5.9 ± 1.38(H) mm, and 250 (250 to 300)µ, respectively. The mean LogMAR visual acuity at the time of presentation was 2.52 ± 0.95. Out of 14 enrolled patients, infection was resolved in 12 (85.7%) patients, whereas 2 (14.3%) patients needed TPK. The median days to resolve were 110 (67 to 150) days. The final mean LogMAR Visual acuity at the end of the follow-up was 1.60 ± 1.3.
The study demonstrates the effective resolution of Acanthamoeba keratitis when treated with early adjuvant photodynamic antimicrobial therapy using Rose Bengal (PDAT-RB).
报告棘阿米巴角膜炎的治疗结果，即在药物治疗（0.02%聚六亚甲基双胍（PH）和0.02%氯己定（CH）联合使用）的基础上早期加用孟加拉玫瑰红光动力抗菌疗法（PDAT-RB）。
根据浸润灶大小<8mm且局限于基质中层、<300µ，并经微生物学确诊来招募患者。在继续使用PHMB+CH的同时，确诊后立即使用0.1%w/v孟加拉玫瑰红和绿色发光二极管（525nm）阵列对患者进行两次PDAT-RB治疗，间隔一周。
共纳入14例患者。所有纳入患者在诊断后5（2.5至11）天内接受了辅助性PDAT-RB治疗。浸润灶的平均直径和中位深度分别为5.7±1.56（垂直）、5.9±1.38（水平）mm和250（250至300）µ。就诊时的平均LogMAR视力为2.52±0.95。14例纳入患者中，12例（85.7%）感染得到解决，而2例（14.3%）患者需要进行穿透性角膜移植术（TPK）。解决感染的中位天数为110（67至150）天。随访结束时的最终平均LogMAR视力为1.60±1.3。
该研究表明，早期使用孟加拉玫瑰红光动力抗菌疗法（PDAT-RB）进行辅助治疗可有效治愈棘阿米巴角膜炎。
