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通过 COPD 评估测试 (CAT) 对囊性纤维化患者的健康相关生活质量进行简单测量 - 一项初步研究。

Easy measurement of health related quality of life in patients with cystic fibrosis by the COPD assessment test (CAT) - A pilot study.

机构信息

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Medicine, Saarland University Hospital, Homburg, Germany.

出版信息

Respir Med. 2020 Jul;168:105992. doi: 10.1016/j.rmed.2020.105992. Epub 2020 Apr 30.

DOI:10.1016/j.rmed.2020.105992

PMID:32469708

Abstract

BACKGROUND

Quality of life (QOL) is an important patient-related outcome (PRO) in patients with cystic fibrosis (CF). There are several QOL questionnaires like the "Cystic Fibrosis Questionnaire Revised" (CFQ-R) or the "St George's Respiratory Questionnaire" (SGRQ) that are well validated in CF. The aim of the study was to evaluate whether the easily applicable "COPD assessment test" (CAT) can be used in CF patients.

METHODS

42 CF patients were recruited within the PulmoHOM study, a prospective, observational cohort study. The CAT, the SGRQ and the CFQ-R were handed out to the patients. The spearman's rank correlation coefficient and the Cronbach's α coefficient were used for the statistical analysis.

RESULTS

The internal consistencies of the CAT, SGRQ and the CFQ-R were high (Cronbach's α coefficients = 0.89, 0.91 and 0.83). There were significant correlations between the CAT and the total score of the SGRQ (r = 0.851, p < 0.01), between the CAT and many items of the CFQ-R (physical score of the CFQ-R and total score of the CAT: r = -0.872, p < 0.01) and between the SGRQ and the CFQ-R (physical score of the CFQ-R and total score of the SGRQ: r = -0.878, p < 0.01).

CONCLUSION

The main finding was the high correlation between the CAT and the validated questionnaires in CF. The CAT is a PRO instrument that can be filled quickly and that correlates well with the CFQ-R. The CAT or similar tools might be applicable in the care of CF patients.

摘要

背景

生活质量（QOL）是囊性纤维化（CF）患者的一个重要的患者相关结局（PRO）。有几种 QOL 问卷，如“囊性纤维化问卷修订版”（CFQ-R）或“圣乔治呼吸问卷”（SGRQ），在 CF 中得到了很好的验证。本研究的目的是评估是否可以将易于应用的“COPD 评估测试”（CAT）用于 CF 患者。

方法

在一项前瞻性观察队列研究 PulmoHOM 研究中，招募了 42 名 CF 患者。向患者发放 CAT、SGRQ 和 CFQ-R。采用 Spearman 秩相关系数和 Cronbach's α 系数进行统计分析。

结果

CAT、SGRQ 和 CFQ-R 的内部一致性较高（Cronbach's α 系数分别为 0.89、0.91 和 0.83）。CAT 与 SGRQ 总分（r=0.851，p<0.01）、CAT 与 CFQ-R 多项（CFQ-R 身体评分和 CAT 总分：r=-0.872，p<0.01）以及 SGRQ 与 CFQ-R（CFQ-R 身体评分和 SGRQ 总分：r=-0.878，p<0.01）之间存在显著相关性。