Challa V S A, Nune K C, Gong N, Misra R D K
Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX, 79968, USA; ArcelorMittal, Global R&D Center, 3001 E. Columbus Drive, East Chicago, IN, 463121, USA.
Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX, 79968, USA.
J Mech Behav Biomed Mater. 2020 Aug;108:103815. doi: 10.1016/j.jmbbm.2020.103815. Epub 2020 Apr 26.
The implant surface and tissue experience strain when micro-motion occurs at the bone-implant interface under physiological loading. Moreover, strain is also introduced on the surface during mechanical processing of biomedical devices. Both these situations can induce phase transformation depending on the degree of stability of the microstructural constituents. In this regard, we elucidate here the interplay between mechanically-induced phase transformation (strain-induced martensite) in austenitic stainless steel on osteoblast functions. Strain-induced martensite significantly impacted cellular functions, notably, cell attachment, cell-surface interactions, proliferation, and synthesis of prominent proteins (fibronectin, actin, and vinculin). Strain-induced martensite favorably modulated cellular activity and contributed to small differences in hydrophilicity in relation to the non-strained austenitic stainless steel surface. The study provides a pathway for tuning biological functionality via microstructural control facilitated by mechanical strain.
在生理负荷下，当骨-植入物界面发生微动时，植入物表面和组织会受到应变。此外，在生物医学设备的机械加工过程中，表面也会产生应变。这两种情况都可能根据微观结构成分的稳定程度诱导相变。在这方面，我们在此阐明奥氏体不锈钢中机械诱导相变（应变诱导马氏体）与成骨细胞功能之间的相互作用。应变诱导马氏体显著影响细胞功能，特别是细胞附着、细胞-表面相互作用、增殖以及重要蛋白质（纤连蛋白、肌动蛋白和纽蛋白）的合成。应变诱导马氏体有利地调节细胞活性，并导致与未应变的奥氏体不锈钢表面相比亲水性存在微小差异。该研究提供了一条通过机械应变促进的微观结构控制来调节生物功能的途径。
