Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX 79968, USA.
Department of Mechanical Engineering, The University of Oulu, P.O. Box 4200, 90014 Oulu, Finland.
J Mech Behav Biomed Mater. 2018 Dec;88:185-195. doi: 10.1016/j.jmbbm.2018.08.033. Epub 2018 Aug 24.
Considering that micromotions generated at the bone-implant interface under physiological loading introduce mechanical strain on the tissue and surface of the implant and that strain can be introduced during processing of the biomedical device, we elucidate here the interplay between mechanically-induced nanoscale twinning in austenitic stainless steel on osteoblast functions. Mechanically-induced nanoscale twinning significantly impacted cell attachment, cell-substrate interactions, proliferation, and subsequent synthesis of prominent proteins (fibronectin, actin, and vinculin). Twinning was beneficial in favorably modulating cellular activity and contributed to small differences in hydrophilicity and nanoscale roughness in relation to the untwinned surface.
考虑到生理负荷下在骨-植入物界面产生的微动会在组织和植入物表面产生机械应变，并且在生物医学设备的加工过程中也会产生应变，我们在这里阐明了机械诱导的奥氏体不锈钢中纳米孪晶与成骨细胞功能之间的相互作用。机械诱导的纳米孪晶显著影响细胞附着、细胞-基底相互作用、增殖以及随后突出蛋白（纤连蛋白、肌动蛋白和 vinculin）的合成。孪晶有利于有利地调节细胞活性，并有助于亲水性能和纳米级粗糙度相对于未孪晶表面的微小差异。
