Cuomo V, Cagiano R, De Salvia M A, Restani P, Galimberti R, Colonna S, Racagni G, Galli C L
Institute of Pharmacology, University of Bari, Italy.
Neurotoxicol Teratol. 1988 Sep-Oct;10(5):465-9. doi: 10.1016/0892-0362(88)90009-8.
Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
出生后早期接触吗啡会显著影响从巢穴中取出的幼鼠的超声发声。具体而言，在接受吗啡治疗的动物中，叫声频率、声压级和频率范围显著降低；此外，吗啡给药显著增加了叫声的持续时间。相反，源自乳蛋白（β-酪蛋白）酶促消化的阿片肽β-酪蛋白吗啡（β-CMS）以及阿片拮抗剂（如纳洛酮）均未对超声发声产生显著影响。本文结合阿片系统在幼小动物分离应激诱导发声中的作用对研究结果进行了讨论。
