Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College Affiliated to Huazhong University of Science and Technology, Wuhan, Hubei, China.
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington.
J Med Virol. 2020 Oct;92(10):2205-2208. doi: 10.1002/jmv.26068. Epub 2020 Jun 12.
Acute respiratory distress syndrome and coagulopathy played an important role in morbidity and mortality of severe COVID-19 patients. A higher frequency of pulmonary embolism (PE) than expected in COVID-19 patients was recently reported. The presenting symptoms for PE were untypical including dyspnea, which is one of the major symptoms in severe COVID-19, especially in those patients with acute respiratory distress syndrome (ARDS). We reported two COVID-19 cases with coexisting complications of PE and ARDS, aiming to consolidate the emerging knowledge of this global health emergency and raise the awareness that the hypoxemia or severe dyspnea in COVID-19 may be related to PE and not necessarily always due to the parenchymal disease.
急性呼吸窘迫综合征和凝血功能障碍在重症 COVID-19 患者的发病率和死亡率中起着重要作用。最近有报道称,COVID-19 患者的肺栓塞(PE)发生率高于预期。PE 的临床表现不典型,包括呼吸困难,这是重症 COVID-19 的主要症状之一,尤其是在急性呼吸窘迫综合征(ARDS)患者中。我们报告了两例 COVID-19 合并 PE 和 ARDS 的病例,旨在总结这一全球卫生紧急事件的新知识,并提高认识,即 COVID-19 患者的低氧血症或严重呼吸困难可能与 PE 有关,而不一定总是由于实质疾病。