Melby K, Kildebo S
Department of Microbiology, Ullevål University Hospital, Oslo, Norway.
NIPH Ann. 1988 Dec;11(2):47-52.
Sera from 74 patients from the Oslo area and 21 from Northern Norway with compylobacteriosis were analysed for antibodies against an antigen mixture comprising seven Campylobacter jejuni/coli strains including a PEN 0:6,7 isolate representing the most common serotype in Northern Norway. Seventy-seven per cent of the campylobacter patients from the Oslo area and 86% from Northern Norway had elevated antibody levels. Thirty-seven out of 57 (65%) seropositive patients from Oslo and 12 out of 18 (67%) from Northern Norway were positive in more than one immunoglobulin class. None of the patients, all from Northern Norway (N = 56), with inflammatory bowel disease i.e. Mb. Crohn or ulcerative colitis diagnosed for the first time, had elevated antibody levels in two immunoglobulin classes. Apparently campylobacteriosis is not associated with the precipitation of these diseases. Two sets of blood donor sera, from Oslo (N = 28) and Tromsø (N = 37) respectively, served as reference. The IgG antibody levels against C. jejuni/coli antigens in the blood donor group from Tromsø were higher than in the Oslo group.
对来自奥斯陆地区的74名弯曲杆菌病患者以及来自挪威北部的21名弯曲杆菌病患者的血清进行了分析，检测其针对包含7种空肠弯曲菌/结肠弯曲菌菌株的抗原混合物的抗体，其中包括一株代表挪威北部最常见血清型的PEN 0:6,7分离株。来自奥斯陆地区的弯曲杆菌病患者中有77%、来自挪威北部的患者中有86%抗体水平升高。来自奥斯陆的57名血清阳性患者中有37名（65%）、来自挪威北部的18名患者中有12名（67%）在不止一种免疫球蛋白类别中呈阳性。所有来自挪威北部（N = 56）、首次被诊断患有炎症性肠病（即克罗恩病或溃疡性结肠炎）的患者，均无两种免疫球蛋白类别抗体水平升高的情况。显然，弯曲杆菌病与这些疾病的发作并无关联。分别来自奥斯陆（N = 28）和特罗姆瑟（N = 37）的两组献血者血清用作对照。特罗姆瑟献血者组中针对空肠弯曲菌/结肠弯曲菌抗原的IgG抗体水平高于奥斯陆组。
