Ankara University, Faculty of Medicine, Department of Psychiatry.
Ankara University, Faculty of Medicine, Department of Psychiatry.
Psychiatry Res. 2020 Aug;290:113065. doi: 10.1016/j.psychres.2020.113065. Epub 2020 May 21.
Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of this study was to examine the association between OCD and subclinical inflammatory markers, namely neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in adult patients and to investigate the association between antidepressant medications and NLR, PLR. Electronic medical records(EMR) of 24,635 patients aged 18-64 were reviewed and after exclusion of comorbid psychiatric and medical diagnosis 135 EMR of OCD patients were included into final analyses and compared with the healthy control group (n=133). Blood cell counts were noted to calculate NLR and PLR. Medications of patients were gathered from all patients to calculate fluoxetine-equivalent-dose(FED) to examine the effects of antidepressants on NLR and PLR. NLR and PLR were significantly higher in OCD. Contrary to the correlation of FED with NLR, PLR was found to not correlate with FED. Hence, PLR would be considered as a robust biomarker to medication effect contrary to NLR. OCD was significantly predicted by both NLR and PLR in logistic regression analyzes.
强迫症（OCD）的特征是出现不受欢迎、侵入性和令人不安的想法或图像，这些想法或图像引起焦虑，并导致重复的行为或精神动作，以减轻这些想法或图像。鉴于 OCD 的病因学存在争议，以及炎症在 OCD 中的作用的证据不断增加，本研究旨在检查 OCD 与亚临床炎症标志物（即中性粒细胞与淋巴细胞比值[NLR]和血小板与淋巴细胞比值[PLR]）之间的关联，并探讨抗抑郁药物与 NLR 和 PLR 之间的关联。回顾了 24635 名年龄在 18-64 岁的患者的电子病历（EMR），排除了合并的精神和医学诊断后，将 135 名 OCD 患者的 EMR 纳入最终分析，并与健康对照组（n=133）进行比较。记录血细胞计数以计算 NLR 和 PLR。从所有患者中收集药物信息以计算氟西汀等效剂量（FED），以检查抗抑郁药对 NLR 和 PLR 的影响。NLR 和 PLR 在 OCD 患者中显著升高。与 FED 与 NLR 的相关性相反，发现 PLR 与 FED 不相关。因此，与 NLR 相比，PLR 将被视为一种稳健的药物效应生物标志物。在逻辑回归分析中，NLR 和 PLR 都可以显著预测 OCD。
