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1
Effective treatment of severe COVID-19 patients with tocilizumab.托珠单抗治疗重症 COVID-19 患者有效。
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975. doi: 10.1073/pnas.2005615117. Epub 2020 Apr 29.
2
COVID-19 pathophysiology: A review.新型冠状病毒肺炎的病理生理学:综述。
Clin Immunol. 2020 Jun;215:108427. doi: 10.1016/j.clim.2020.108427. Epub 2020 Apr 20.
3
COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.肾移植受者 COVID-19 肺炎成功接受托珠单抗和羟氯喹治疗。
Am J Transplant. 2020 Jul;20(7):1902-1906. doi: 10.1111/ajt.15935. Epub 2020 May 13.
4
Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease.致编辑的信:肥胖作为代谢相关脂肪性肝病患者感染 COVID-19 时病情更严重的风险因素。
Metabolism. 2020 Jul;108:154244. doi: 10.1016/j.metabol.2020.154244. Epub 2020 Apr 19.
5
Atypical presentation of COVID-19 in a frail older person.COVID-19 在体弱老年人中的不典型表现。
Age Ageing. 2020 Jul 1;49(4):523-524. doi: 10.1093/ageing/afaa068.
6
COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy.长期肝移植患者中的新型冠状病毒肺炎:来自意大利伦巴第地区一家移植中心的初步经验。
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):532-533. doi: 10.1016/S2468-1253(20)30116-3. Epub 2020 Apr 9.
7
Global Transplantation COVID Report March 2020.《2020年3月全球移植领域新冠疫情报告》
Transplantation. 2020 Oct;104(10):1974-1983. doi: 10.1097/TP.0000000000003258.
8
Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation?COVID-19 于肾移植受者中的病例报告:免疫抑制是否改变临床特征?
Am J Transplant. 2020 Jul;20(7):1875-1878. doi: 10.1111/ajt.15874. Epub 2020 Apr 9.
9
Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic.冠状病毒与免疫抑制患者:第三次疫情期间的实际情况
Liver Transpl. 2020 Jun;26(6):832-834. doi: 10.1002/lt.25756. Epub 2020 Apr 24.
10
COVID-19: consider cytokine storm syndromes and immunosuppression.2019冠状病毒病:考虑细胞因子风暴综合征和免疫抑制。
Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.

肝移植受者 COVID-19 感染率低且病情较轻:单中心经验。

Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience.

机构信息

Institute of Liver Studies, King's College Hospital, London, UK.

出版信息

Liver Int. 2020 Aug;40(8):1972-1976. doi: 10.1111/liv.14552. Epub 2020 Jun 17.

DOI:10.1111/liv.14552
PMID:32471013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7300707/
Abstract

Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high-risk cohort. The following is a short report on COVID-19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow-up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID-19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self-isolation adherence and/or the 'ideal' level of immunosuppression that favourably modulates the immune response to COVID-19.

摘要

由新型冠状病毒严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)引起的 2019 年冠状病毒病(COVID-19)正在引发当前的全球大流行。免疫抑制患者被视为高危人群。以下是来自一个大容量英国肝移植单位的 5 例肝移植受者(n=5)和一个随访队列较大的 COVID-19 (n=4500)的简短报告。根据这有限的数据,与一般人群和其他实体器官受者相比,肝移植受者 COVID-19 的发病率似乎较低,症状也较轻。这可能与自我隔离的遵守和/或“理想”水平的免疫抑制有关,有利于调节对 COVID-19 的免疫反应。