肝移植受者 COVID-19 感染率低且病情较轻：单中心经验。
Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience.
机构信息
Institute of Liver Studies, King's College Hospital, London, UK.
出版信息
Liver Int. 2020 Aug;40(8):1972-1976. doi: 10.1111/liv.14552. Epub 2020 Jun 17.
Abstract
Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high-risk cohort. The following is a short report on COVID-19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow-up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID-19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self-isolation adherence and/or the 'ideal' level of immunosuppression that favourably modulates the immune response to COVID-19.
摘要
由新型冠状病毒严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）正在引发当前的全球大流行。免疫抑制患者被视为高危人群。以下是来自一个大容量英国肝移植单位的 5 例肝移植受者（n=5）和一个随访队列较大的 COVID-19 （n=4500）的简短报告。根据这有限的数据，与一般人群和其他实体器官受者相比，肝移植受者 COVID-19 的发病率似乎较低，症状也较轻。这可能与自我隔离的遵守和/或“理想”水平的免疫抑制有关，有利于调节对 COVID-19 的免疫反应。
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