Department of Physics, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Department of Physics, University of Lampung, Bandar Lampung 35141, Indonesia.
Biosensors (Basel). 2020 May 27;10(6):55. doi: 10.3390/bios10060055.
A CO laser has the advantages of being high in power and having many laser lines in the 9-11 µm infrared region. Thus, a CO laser photoacoustic spectrometer (PAS) can have a multi-component measurement capability for many gas compounds that have non-zero absorption coefficients at the laser lines, and therefore can be applied for measuring several volatile organic compounds (VOCs) in the human breath. We have developed a CO laser PAS system for detecting acetone in the human breath. Although acetone has small absorption coefficients at the CO laser lines, our PAS system was able to obtain strong photoacoustic (PA) signals at several CO laser lines, with the strongest one being at the 10P20 line. Since at the 10P20 line, ethylene and ammonia also have significant absorption coefficients, these two gases have to be included in a multi-component measurement with acetone. We obtained the lowest detection limit of our system for the ethylene, acetone, and ammonia are 6 ppbv, 11 ppbv, and 31 ppbv, respectively. We applied our PAS system to measure these three VOCs in the breath of three groups of subjects, i.e., patients with lung cancer disease, patients with other lung diseases, and healthy volunteers.
CO 激光器的优点是功率高，在 9-11 µm 红外区域有许多激光线。因此，CO 激光光声光谱仪（PAS）可以对许多在激光线处具有非零吸收系数的气体化合物进行多组分测量，因此可用于测量人体呼吸中的几种挥发性有机化合物（VOC）。我们开发了一种用于检测人体呼吸中丙酮的 CO 激光 PAS 系统。尽管丙酮在 CO 激光线处的吸收系数较小，但我们的 PAS 系统能够在几个 CO 激光线处获得强的光声（PA）信号，最强的信号在 10P20 线处。由于在 10P20 线处，乙烯和氨也有显著的吸收系数，因此这两种气体必须与丙酮一起进行多组分测量。我们的系统对乙烯、丙酮和氨的最低检测限分别为 6 ppbv、11 ppbv 和 31 ppbv。我们将 PAS 系统应用于三组受试者的呼吸中，即肺癌患者、其他肺部疾病患者和健康志愿者。
