Department of Clinical Laboratory, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan; Department of Microbiology and Infectious Disease, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
Department of Clinical Laboratory, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan; Department of Microbiology and Infectious Disease, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
J Infect Chemother. 2020 Sep;26(9):1002-1004. doi: 10.1016/j.jiac.2020.04.026. Epub 2020 May 26.
Staphylococcus argenteus, characterized by the formation of non-pigmented (white) colonies, was recently identified as a new lineage separated from Staphylococcus aureus. However, correct identification of this lineage is difficult because of the similar characteristics to S. aureus. Here, we describe the first known case of keratoconjunctivitis due to S. argenteus in a 64-year-old man with diabetes. The symptoms of the patient were not improved by antibiotic therapy using levofloxacin eye drops (15 mg/mL). The conjunctival scraping was cultured, and coagulase-positive staphylococci forming white colonies were detected. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry confirmed the species as S. argenteus with a spectral score of 1.97. After the antibiotic was changed to vancomycin eye drops (10 mg/mL), the patient's symptom clearly improved. Multi-locus sequence typing showed that this isolate belonged to sequence type 1223, which has been predominantly isolated worldwide. Furthermore, this isolate harbored various virulence genes associated with S. aureus, such as staphylococcal enterotoxins and leukocidin. Since only limited information is available for this organism, further studies are needed to establish the epidemiology of S. argenteus.
金黄色酿脓葡萄球菌的特点是形成非色素（白色）菌落，最近被鉴定为与金黄色葡萄球菌分离的新谱系。然而，由于与金黄色葡萄球菌的特征相似，正确识别该谱系具有一定难度。在这里，我们描述了首例已知的由金黄色酿脓葡萄球菌引起的 64 岁糖尿病患者的角膜炎和结膜炎。患者的症状并未通过左氧氟沙星滴眼液（15mg/ml）的抗生素治疗得到改善。对结膜刮片进行培养，发现了形成白色菌落的凝固酶阳性葡萄球菌。基质辅助激光解吸/电离飞行时间质谱确认该物种为金黄色酿脓葡萄球菌，光谱评分 1.97。将抗生素改为万古霉素滴眼液（10mg/ml）后，患者的症状明显改善。多位点序列分型显示，该分离株属于全球主要分离株的 1223 型序列。此外，该分离株还携带与金黄色葡萄球菌相关的各种毒力基因，如葡萄球菌肠毒素和白细胞毒素。由于对该生物体的信息有限，需要进一步研究以建立金黄色酿脓葡萄球菌的流行病学。
