Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Virulence. 2024 Dec;15(1):2396477. doi: 10.1080/21505594.2024.2396477. Epub 2024 Aug 27.
is a novel species within the complex and can cause serious bloodstream infections (BSIs) in humans, which have been mainly reported in adults, especially the elderly. In this study, we analyzed the molecular characterization of a strain of (22WJ8192) isolated from the peripheral vein blood sample of a seven-month-old female infant in Eastern China. The 22WJ8192 belonged to sequence type (ST)2250 and harbored six antibiotic-resistance genes and 53 virulence genes and was resistant to penicillin. Additionally, we conducted a comparative analysis of the molecular characteristics of sourced from various origins within the dataset, predominantly from the National Center for Biotechnology Information Collection (NCBI) genome database. Antibiotic-resistance genes , , , , , , , and were more prevalent among the strains of human origin. Virulence genes , , , , , and were more prevalent among strains of human origin. The presence of antibiotic-resistance genes , , , , and in strain 22WJ8192 was also more common among strains of human origin in the dataset. Conversely, the antibiotic-resistance genes , , and , typically found in strains of human origin, were not detected in 22WJ8192. Additionally, virulence genes , , , , , and present in 22WJ8192 exhibited a higher prevalence among strains of human origin in the dataset. In conclusion, this study emphasizes the potential of ST2250 to induce severe bloodstream infections in infants, shedding light on the molecular characteristics of this strain.
是 复合体中的一个新物种，可导致人类严重血流感染（BSI），主要在成人中报告，尤其是老年人。在这项研究中，我们分析了从中国东部一名 7 个月大女婴外周静脉血样本中分离出的一株 （22WJ8192）的分子特征。22WJ8192 属于序列型（ST）2250，携带 6 个抗生素耐药基因和 53 个毒力基因，对青霉素耐药。此外，我们对来自不同来源的 进行了分子特征的比较分析，主要来自美国国立生物技术信息中心（NCBI）基因组数据库。抗生素耐药基因 、 、 、 、 、 、 和 在人源菌株中更为普遍。毒力基因 、 、 、 、 和 在人源菌株中更为普遍。抗生素耐药基因 、 、 、 和 在 22WJ8192 株中的存在也在数据集的人源菌株中更为常见。相反，在 22WJ8192 株中未检测到通常在人源菌株中发现的抗生素耐药基因 、 、 和 。此外，在 22WJ8192 株中存在的毒力基因 、 、 、 、 和 在数据集的人源菌株中更为常见。总之，本研究强调了 ST2250 引起婴儿严重血流感染的潜力，揭示了该菌株的分子特征。
