Am J Epidemiol. 2020 Nov 2;189(11):1254-1265. doi: 10.1093/aje/kwaa073.
Diet, lifestyle, and psychosocial factors might influence fertility for men and women, although evidence is mixed, and couple-based approaches are needed for assessing associations with reproductive outcomes. The Impact of Diet, Exercise, and Lifestyle (IDEAL) on Fertility Study is a prospective cohort with contemporaneous detailed follow-up of female partners of men enrolled in the Folic Acid and Zinc Supplementation Trial studying couples seeking infertility treatment (2016-2019). Follow-up of men continued for 6 months, while female partners were followed for 9 months while attempting pregnancy and throughout any resulting pregnancy (up to 18 months). Longitudinal data on diet, physical activity (including measurement via wearable device), sleep, and stress were captured at multiple study visits during this follow-up. A subset of women (IDEALplus) also completed daily journals and a body fat assessment via dual-energy x-ray absorptiometry. IDEAL enrolled 920 women, and IDEALPlus enrolled 218. We demonstrated the ability to enroll women in a prospective cohort study contemporaneous to a partner-enrolled randomized trial. In combination with data collected on male partners, IDEAL data facilitates a couple-based approach to understanding associations between lifestyle factors and infertility treatment outcomes. We describe in detail the study design, recruitment, data collection, lessons learned, and baseline characteristics.
饮食、生活方式和心理社会因素可能会影响男性和女性的生育能力，尽管证据存在差异，并且需要基于夫妇的方法来评估与生殖结局的关联。饮食、运动和生活方式的影响（IDEAL）对生育能力的研究是一项前瞻性队列研究，对参加叶酸和锌补充试验研究寻求不孕治疗的男性伴侣的女性伴侣进行了同期详细随访（2016-2019 年）。对男性的随访持续 6 个月，而女性伴侣在尝试怀孕和任何由此产生的怀孕期间（长达 18 个月）进行了 9 个月的随访。在随访期间的多次研究访问中，纵向收集了关于饮食、身体活动（包括通过可穿戴设备测量）、睡眠和压力的数据。一小部分女性（IDEALplus）还通过双能 X 射线吸收法完成了每日日记和体脂评估。IDEAL 招募了 920 名女性，IDEALPlus 招募了 218 名。我们展示了在与伴侣参加的随机试验同期招募女性参加前瞻性队列研究的能力。结合对男性伴侣收集的数据，IDEAL 数据促进了一种基于夫妇的方法来理解生活方式因素与不孕治疗结局之间的关联。我们详细描述了研究设计、招募、数据收集、经验教训和基线特征。
