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中国髌股关节骨关节炎的高患病率:一项基于多中心人群的骨关节炎研究。

High prevalence of patellofemoral osteoarthritis in China: a multi-center population-based osteoarthritis study.

作者信息

Li Zhanglai, Liu Qiang, Zhao Changsheng, Gao Xiwu, Han Wenchao, Stefanik Joshhua J, Jin Qunhua, Lin Jianhao, Zhang Yuqing

机构信息

Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, China.

Arthritis Clinic and Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.

出版信息

Clin Rheumatol. 2020 Dec;39(12):3615-3623. doi: 10.1007/s10067-020-05110-7. Epub 2020 May 29.

Abstract

BACKGROUND

To describe the prevalence and risk factors of patellofemoral osteoarthritis (PFOA) among Chinese residents.

METHODS

A multi-center population-based osteoarthritis study was conducted in 2014. Residents aged ≥ 50 years old were recruited using a cluster sampling method. Subjects completed a home interview and physical examination and had skyline view of radiographs at patellofemoral (PF) joints. Radiographs were read by two trained musculoskeletal researchers, and discordance of a subject's PFOA status between two readers was adjudicated with a third musculoskeletal researcher present. Radiographic OA at PF joint was defined if osteophytes (OST) score was ≥ 2 or if joint space narrowing (JSN) score was ≥ 2 with concurrent grade 1 OST in the PF joint.

RESULTS

Of 3446 subjects (63.0% women) included in this analysis, the prevalence of radiographic PFOA was 23.9% (20.5% men vs. 25.8% women). Prevalence of lateral radiographic OA was higher than medial radiographic OA at PF joint. Grades of both osteophytes and joint space narrowing in the lateral patellofemoral compartment were higher than those in the medial patellofemoral compartment (all P values < 0.001). Women, older age, higher BMI, and fewer years of education were significantly associated with higher prevalence of radiographic PFOA, osteophytes, and joint space narrowing.

CONCLUSION

Prevalence of radiographic PFOA was high among Chinese population. Key Points • The multi-center population-based osteoarthritis study shows the prevalence of radiographic PFOA was high among Chinese population. • Older age, female gender, obesity, and few years of education were associated with a high risk of PFOA. • Prevalence of lateral radiographic OA was higher than medial radiographic OA at PF joint.

摘要

背景

描述中国居民中髌股关节炎(PFOA)的患病率及危险因素。

方法

2014年开展了一项基于多中心人群的骨关节炎研究。采用整群抽样方法招募年龄≥50岁的居民。受试者完成了家庭访谈和体格检查,并拍摄了髌股(PF)关节的天际线位X线片。由两名经过培训的肌肉骨骼研究人员阅读X线片,若两名阅片者对某受试者的PFOA状态判断不一致,则由第三名肌肉骨骼研究人员进行裁定。如果骨赘(OST)评分≥2或关节间隙狭窄(JSN)评分≥2且PF关节同时伴有1级OST,则定义为PF关节的X线骨关节炎。

结果

本分析纳入的3446名受试者中(女性占63.0%),X线PFOA的患病率为23.9%(男性为20.5%,女性为25.8%)。PF关节外侧X线骨关节炎的患病率高于内侧。外侧髌股关节腔的骨赘和关节间隙狭窄程度均高于内侧髌股关节腔(所有P值<0.001)。女性、年龄较大、体重指数较高以及受教育年限较少与X线PFOA、骨赘和关节间隙狭窄的较高患病率显著相关。

结论

中国人群中X线PFOA的患病率较高。要点:• 基于多中心人群的骨关节炎研究表明,中国人群中X线PFOA的患病率较高。• 年龄较大、女性、肥胖和受教育年限较少与PFOA的高风险相关。• PF关节外侧X线骨关节炎的患病率高于内侧。

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