Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC 27599-7280, USA.
Osteoarthritis Cartilage. 2009 Dec;17(12):1554-61. doi: 10.1016/j.joca.2009.07.011. Epub 2009 Sep 1.
To examine racial differences in tibiofemoral joint (TFJ) and patellofemoral joint (PFJ) radiographic osteoarthritis in African-American (AA) and Caucasian men and women.
Multiple logistic regression was used to evaluate cross-sectional associations between race and tibiofemoral osteoarthritis (TF-OA) and the presence, severity and location of individual radiographic features of tibiofemoral joint osteoarthritis [TFJ-OA] (osteophytes, joint space narrowing [JSN], sclerosis and cysts) and patellofemoral joint osteoarthritis (PFJ-OA) (osteophytes, JSN and sclerosis), using data from the Johnston County Osteoarthritis Project. Proportional odds ratios (POR) assessed severity of TF-OA, TFJ and PFJ osteophytes, and JSN, adjusting for confounders. Generalized estimating equations accounted for auto-correlation of knees.
Among 3187 participants (32.5% AAs; 62% women; mean age 62 years), 6300 TFJ and 1957 PFJ were included. Compared to Caucasians, AA men were more likely to have TF-OA (adjusted odds ratio [aOR]=1.36; 95% CI, 1.00-1.86); tri-compartmental TFJ and PFJ osteophytes (aOR=3.06; 95%CI=1.96-4.78), and TFJ and PFJ sclerosis. AA women were more likely than Caucasian to have medial TFJ and tri-compartmental osteophytes (aOR=2.13; 1.55-2.94), and lateral TFJ sclerosis. AAs had more severe TF-OA than Caucasians (adjusted cumulative odds ratio [aPOR]=2.08; 95% CI, 1.19-3.64 for men; aPOR=1.56; 95% CI, 1.06-2.29 for women) and were more likely to have lateral TFJ JSN.
Compared to Caucasians, AAs were more likely to have more severe TF-OA; tri-compartmental disease; and lateral JSN. Further research to clarify the discrepancy between radiographic features in OA among races appears warranted.
研究非裔美国人和白人男女的胫股关节（TFJ）和髌股关节（PFJ）放射影像学骨关节炎的种族差异。
使用来自约翰斯顿县骨关节炎项目的数据，多变量逻辑回归评估种族与胫股关节炎性骨关节炎（TF-OA）以及胫股关节（TFJ-OA）（骨赘、关节间隙狭窄[JSN]、硬化和囊肿）和髌股关节骨关节炎（PFJ-OA）（骨赘、JSN 和硬化）的放射影像学特征之间的横断面关联。比例优势比（POR）评估 TF-OA、TFJ 和 PFJ 骨赘以及 JSN 的严重程度，同时调整混杂因素。广义估计方程考虑了膝关节的自相关。
在 3187 名参与者（32.5%为非裔美国人；62%为女性；平均年龄 62 岁）中，纳入了 6300 个 TFJ 和 1957 个 PFJ。与白人相比，非裔美国男性更有可能患 TF-OA（调整后的优势比[aOR]=1.36；95%CI，1.00-1.86）；三部位 TFJ 和 PFJ 骨赘（aOR=3.06；95%CI=1.96-4.78），以及 TFJ 和 PFJ 硬化。非裔美国女性比白人更有可能患有内侧 TFJ 和三部位骨赘（aOR=2.13；1.55-2.94），以及外侧 TFJ 硬化。非裔美国人比白人患 TF-OA 更严重（调整后的累积优势比[aPOR]=2.08；95%CI，男性为 1.19-3.64；aPOR=1.56；95%CI，女性为 1.06-2.29），并且更有可能出现外侧 TFJ JSN。
与白人相比，非裔美国人更有可能患更严重的 TF-OA；三部位疾病；以及外侧 JSN。进一步研究澄清不同种族之间 OA 的放射影像学特征差异似乎是必要的。
