Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado, Takatsu-Ku, Kawasaki, Kanagawa, Japan.
Sci Rep. 2023 Oct 5;13(1):16750. doi: 10.1038/s41598-023-42404-7.
The existing methods for analyzing patellofemoral (PF) osteoarthritis (OA) are limited. Our purpose was to clarify the frequency, localization, and morphological progression of PFOA by observing three-dimensional (3D) magnetic resonance (MR) images from a cohort population. The subjects were 561 patients aged 30-79 years from the Kanagawa Knee Study who had not visited a hospital for more than three consecutive months for knee symptoms. MR images of the PF joints, separated into the medial and lateral types, were presented in order of the highest to lowest patella cartilage area ratios. Cartilage defects in the patella were detected in 37 subjects (6.6%). Medial lesions (4.6%) were significantly more frequent than lateral lesions (2.0%) (p < 0.01). For both medial and lateral lesions, the patellar cartilage defects were divided into confined and unconfined types. The 3D MR images of the PF joint showed that the patellar cartilage defect occurred along each ridge of the femoral trochlea. The 3D MR images revealed a 6.6% prevalence of patellar cartilage defects, higher in the medial than lateral regions. The 3D MR images can easily determine PF morphology and cartilage defect location, making them useful in understanding the pathophysiology and etiology of PFOA.
现有的髌股（PF）骨关节炎（OA）分析方法存在局限性。我们的目的是通过观察来自队列人群的三维（3D）磁共振（MR）图像来阐明 PFOA 的频率、定位和形态进展。研究对象为来自神奈川膝关节研究的 561 名 30-79 岁的患者，这些患者连续三个月以上因膝关节症状未到医院就诊。按照髌股软骨面积比从高到低的顺序，对 PF 关节进行了内侧和外侧分型的 MR 图像。在 37 名患者（6.6%）中检测到髌骨关节软骨缺损。内侧病变（4.6%）明显比外侧病变（2.0%）更常见（p<0.01）。对于内侧和外侧病变，髌股软骨缺损分为局限型和非局限型。PF 关节的 3D MR 图像显示髌股软骨缺损发生在股骨滑车的每个脊上。3D MR 图像显示髌股软骨缺损的患病率为 6.6%，内侧比外侧更常见。3D MR 图像可以轻松确定 PF 形态和软骨缺损位置，有助于了解 PFOA 的病理生理学和病因。
