前瞻性多中心评估先进的细胞外基质在伤口管理中的应用。
Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management.
机构信息
Rose Raizman, RN-EC, NSWOC, MSc, is nurse practitioner and enterostomal therapist, Centenary Hospital, Toronto, Ontario, Canada. Rosemary Hill, RN, CWOCN, CETN(C), is Certified Wound Ostomy Continence Clinician, Lions Gate Hospital, North Vancouver, British Columbia; Kevin Woo, PhD, RN, NSWOC, WOCC(C), FAPWCA, is Associate Professor, Queens University, Kingston, Ontario. Acknowledgments: Aroa Biosurgery Limited (New Zealand) provided study products, editorial assistance, and travel grants for conference attendance to the authors. Endoform is currently available in the following countries: New Zealand, Canada, US, Germany, Thailand, Jordan, and Mexico. The authors have disclosed no other financial relationships related to this article. Submitted December 20, 2019; accepted in revised form February 19, 2020.
出版信息
Adv Skin Wound Care. 2020 Aug;33(8):437-444. doi: 10.1097/01.ASW.0000667052.74087.d6.
OBJECTIVE
To evaluate an advanced extracellular matrix made of ovine forestomach matrix (OFM) for healing a variety of wound types.
METHODS
Participants were enrolled from inpatient, outpatient, and home healthcare settings. The OFM was used to treat all wounds and applied to the wound bed every 3 to 7 days until closure.
RESULTS
Researchers enrolled 29 participants with 33 wounds. Average time to wound closure was 8.2 weeks, the percentage of wounds that reduced in size by 50% or more at 4 weeks was 64%, the average wound area reduction at 4 weeks was 66%, and 73% of wounds had closed at 12 weeks. No adverse effects were observed.
CONCLUSIONS
This represents the first Canadian evaluation of OFM for the treatment of wounds, and the positive healing outcomes observed could support more widespread adoption of this matrix.
目的
评估一种由绵羊网胃基质（OFM）制成的先进细胞外基质，以治疗各种类型的伤口。
方法
参与者来自住院、门诊和家庭保健环境。OFM 被用于治疗所有伤口，每 3 至 7 天应用于伤口床，直至闭合。
结果
研究人员招募了 29 名参与者，共有 33 处伤口。伤口闭合的平均时间为 8.2 周，4 周时伤口缩小 50%或更多的百分比为 64%，4 周时的平均伤口面积减少率为 66%，12 周时 73%的伤口已经闭合。未观察到不良反应。
结论
这是加拿大首次对 OFM 治疗伤口进行评估，观察到的积极愈合结果可能支持更广泛地采用这种基质。
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