Department of Dermatology, University of Pisa, Italy.
Adv Skin Wound Care. 2010 Jan;23(1):34-8. doi: 10.1097/01.ASW.0000363485.17224.26.
In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers.
Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue.
Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05).
Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.
本研究旨在比较生物细胞外基质与湿性伤口敷料在治疗混合动静脉和静脉溃疡方面的疗效。
评估患者的完全伤口愈合、换药时间和肉芽组织形成情况。
细胞外基质治疗的溃疡平均在 5.4 周内完全愈合，而湿性伤口敷料对照组则为 8.3 周（P=.02）。在评估的主要时间点（8 周），细胞外基质治疗的溃疡中 80%完全闭合，而对照组为 65%（P<.05）。细胞外基质治疗组在换药时间（P<.05）和肉芽组织形成百分比（P<.05）方面也有显著的统计学差异。
总的来说，生物细胞外基质在治疗混合动静脉或静脉溃疡患者方面比湿性伤口敷料更有效。
