恢复衰老干细胞功能：当前进展与未来方向。
Restoring aged stem cell functionality: Current progress and future directions.
作者信息
Spehar Kevin, Pan Andrew, Beerman Isabel
机构信息
Epigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on Aging, NIH, BRC, Baltimore, Maryland, USA.
Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology, Atlanta, Georgia, USA.
出版信息
Stem Cells. 2020 Sep;38(9):1060-1077. doi: 10.1002/stem.3234. Epub 2020 Jun 18.
Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [Cell 2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields, and various techniques have been employed to mitigate the decline of stem cell function both in vitro and in vivo. While some techniques developed in model organisms are not directly translatable to humans, others show promise in becoming clinically relevant to delay or even mitigate negative phenotypes associated with aging. This review focuses on diet, treatment, and small molecule interventions that provide evidence of functional improvement in at least one type of aged adult stem cell.
干细胞功能障碍是衰老的一个标志，与人类和其他哺乳动物的身体及认知能力下降有关[《细胞》2013年；153:1194]。因此，它已成为衰老和干细胞领域一个活跃的研究领域，并且已经采用了各种技术来减轻体外和体内干细胞功能的衰退。虽然在模式生物中开发的一些技术不能直接应用于人类，但其他一些技术有望在临床上用于延缓甚至减轻与衰老相关的负面表型。本综述重点关注饮食、治疗和小分子干预措施，这些措施为至少一种类型的老年成体干细胞的功能改善提供了证据。
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