恢复衰老干细胞功能：当前进展与未来方向。
Restoring aged stem cell functionality: Current progress and future directions.
作者信息
Spehar Kevin, Pan Andrew, Beerman Isabel
机构信息
Epigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on Aging, NIH, BRC, Baltimore, Maryland, USA.
Wallace H. Coulter Department of Biomedical Engineering , Georgia Institute of Technology, Atlanta, Georgia, USA.
出版信息
Stem Cells. 2020 Sep;38(9):1060-1077. doi: 10.1002/stem.3234. Epub 2020 Jun 18.
Abstract
Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [Cell 2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields, and various techniques have been employed to mitigate the decline of stem cell function both in vitro and in vivo. While some techniques developed in model organisms are not directly translatable to humans, others show promise in becoming clinically relevant to delay or even mitigate negative phenotypes associated with aging. This review focuses on diet, treatment, and small molecule interventions that provide evidence of functional improvement in at least one type of aged adult stem cell.
摘要
干细胞功能障碍是衰老的一个标志，与人类和其他哺乳动物的身体及认知能力下降有关[《细胞》2013年；153:1194]。因此，它已成为衰老和干细胞领域一个活跃的研究领域，并且已经采用了各种技术来减轻体外和体内干细胞功能的衰退。虽然在模式生物中开发的一些技术不能直接应用于人类，但其他一些技术有望在临床上用于延缓甚至减轻与衰老相关的负面表型。本综述重点关注饮食、治疗和小分子干预措施，这些措施为至少一种类型的老年成体干细胞的功能改善提供了证据。
相似文献
1
Restoring aged stem cell functionality: Current progress and future directions.恢复衰老干细胞功能：当前进展与未来方向。
Stem Cells. 2020 Sep;38(9):1060-1077. doi: 10.1002/stem.3234. Epub 2020 Jun 18.
2
Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation.干细胞和祖细胞的衰老：机制、对治疗潜力的影响及年轻化
Rejuvenation Res. 2016 Feb;19(1):3-12. doi: 10.1089/rej.2015.1676.
3
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.肌肉干细胞群体的再生恢复了受伤老年肌肉的力量。
Nat Med. 2014 Mar;20(3):255-64. doi: 10.1038/nm.3464. Epub 2014 Feb 16.
4
Stem cells: Repeat to fade.干细胞：重复以淡化。
Nature. 2012 Dec 6;492(7427):S12-3. doi: 10.1038/492S12a.
5
Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation.干细胞衰老与年龄相关的心血管疾病：体外干细胞复壮治疗的前景
Curr Drug Targets. 2015;16(8):780-5. doi: 10.2174/1389450116666141205153258.
6
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.线粒体代谢检查点在干细胞衰老和 rejuvenation 中的作用。
Mech Ageing Dev. 2020 Jun;188:111254. doi: 10.1016/j.mad.2020.111254. Epub 2020 Apr 25.
7
Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan.延缓衰老的干细胞：延长健康和寿命的治疗策略。
FEBS Lett. 2024 Nov;598(22):2776-2787. doi: 10.1002/1873-3468.14865. Epub 2024 Apr 11.
8
Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation.血管衰老：血管年轻化的分子机制和潜在治疗方法。
Ageing Res Rev. 2017 Aug;37:94-116. doi: 10.1016/j.arr.2017.05.006. Epub 2017 Jun 1.
9
Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.衰老过程中基于干细胞疗法的年轻化策略
Cell Stem Cell. 2017 Feb 2;20(2):161-175. doi: 10.1016/j.stem.2017.01.008.
10
When stem cells grow old: phenotypes and mechanisms of stem cell aging.当干细胞衰老时：干细胞衰老的表型与机制
Development. 2016 Jan 1;143(1):3-14. doi: 10.1242/dev.130633.
引用本文的文献
1
Gland- and cell-level heterogeneity in the prostate: A narrative review of related diseases.前列腺的腺体和细胞水平异质性：相关疾病的叙述性综述
Curr Urol. 2025 Jul;19(4):241-246. doi: 10.1097/CU9.0000000000000269. Epub 2025 Jan 17.
2
Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications.结肠衰老与结直肠癌：一种不容忽视的相互作用及其转化意义
Biology (Basel). 2025 Jul 3;14(7):805. doi: 10.3390/biology14070805.
3
Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care.脊髓损伤护理中基于个性化干细胞的再生治疗
Int J Mol Sci. 2025 Apr 19;26(8):3874. doi: 10.3390/ijms26083874.
4
Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions.Yes相关蛋白介导的褪黑素在氧化应激条件下调节牙周膜干细胞的功能。
World J Stem Cells. 2024 Nov 26;16(11):926-943. doi: 10.4252/wjsc.v16.i11.926.
5
Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies.肠道衰老：从正常状态衰退至产生不良影响及老年治疗策略
Heliyon. 2024 Sep 12;10(19):e37883. doi: 10.1016/j.heliyon.2024.e37883. eCollection 2024 Oct 15.
6
Regenerative Medicine: Case Study for Understanding and Anticipating Emerging Science and Technology.再生医学：理解和预测新兴科学技术的案例研究。
NAM Perspect. 2023 Nov 15;2023. doi: 10.31478/202311d. eCollection 2023.
7
The Possible Roles of -alanine and L-carnosine in Anti-aging.β-丙氨酸和L-肌肽在抗衰老中的可能作用。
Curr Med Chem. 2025;32(1):6-22. doi: 10.2174/0109298673263561231117054447.
8
From premature birth to premature kidney disease: does accelerated aging play a role?从早产到早发性肾脏疾病：加速老化是否起作用？
Pediatr Nephrol. 2024 Jul;39(7):2001-2013. doi: 10.1007/s00467-023-06208-1. Epub 2023 Nov 10.
9
Rejuvenation of Senescent Mesenchymal Stem Cells to Prevent Age-Related Changes in Synovial Joints.衰老间充质干细胞的年轻化以预防滑液关节的与年龄相关的变化。
Cell Transplant. 2023 Jan-Dec;32:9636897231200065. doi: 10.1177/09636897231200065.
10
Chronic inflammation and the hallmarks of aging.慢性炎症与衰老的特征。
Mol Metab. 2023 Aug;74:101755. doi: 10.1016/j.molmet.2023.101755. Epub 2023 Jun 15.
本文引用的文献
1
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.瞬时非整合性表达核重编程因子促进人细胞衰老的多方面改善。
Nat Commun. 2020 Mar 24;11(1):1545. doi: 10.1038/s41467-020-15174-3.
2
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.NAD+ 治疗与年龄相关的退行性疾病：效益/风险分析。
Exp Gerontol. 2020 Apr;132:110831. doi: 10.1016/j.exger.2020.110831. Epub 2020 Jan 7.
3
Direct conversion of human fibroblasts into therapeutically active vascular wall-typical mesenchymal stem cells.将人成纤维细胞直接转化为具有治疗活性的血管壁典型间充质干细胞。
Cell Mol Life Sci. 2020 Sep;77(17):3401-3422. doi: 10.1007/s00018-019-03358-0. Epub 2019 Nov 11.
4
Rapamycin for longevity: opinion article.雷帕霉素与长寿：观点文章
Aging (Albany NY). 2019 Oct 4;11(19):8048-8067. doi: 10.18632/aging.102355.
5
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.二甲双胍通过激活衰老的干细胞来恢复中枢神经系统的髓鞘再生能力。
Cell Stem Cell. 2019 Oct 3;25(4):473-485.e8. doi: 10.1016/j.stem.2019.08.015.
6
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.衰老影响小鼠肌肉干细胞中的 DNA 甲基化漂移和转录细胞间变异性。
Nat Commun. 2019 Sep 25;10(1):4361. doi: 10.1038/s41467-019-12293-4.
7
Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production AMPK activation.白藜芦醇通过抑制内源性活性氧的产生和 AMPK 的激活来促进衰老的骨髓间充质干细胞的成骨分化。
Redox Rep. 2019 Dec;24(1):62-69. doi: 10.1080/13510002.2019.1658376.
8
Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.通过同时对两个信号决定因素进行药理学调节来实现脑、肝和肌肉的年轻化，这两个信号决定因素会随着年龄的增长而呈相反方向变化。
Aging (Albany NY). 2019 Aug 15;11(15):5628-5645. doi: 10.18632/aging.102148.
9
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.烟酰胺核糖苷增强衰老人类骨骼肌中的 NAD 代谢组，并诱导转录组和抗炎特征。
Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043.
10
DNA damage in aging, the stem cell perspective.衰老中的 DNA 损伤：干细胞视角。
Hum Genet. 2020 Mar;139(3):309-331. doi: 10.1007/s00439-019-02047-z. Epub 2019 Jul 19.
Zotero 插件