BN - 52021可保护豚鼠免受心脏过敏反应的影响。
BN-52021 protects guinea-pig from heart anaphylaxis.
作者信息
Magni F, Rossoni G, Berti F
机构信息
Institute of Pharmacological Sciences, University of Milan, Italy.
出版信息
Pharmacol Res Commun. 1988 Dec;20 Suppl 5:75-8. doi: 10.1016/s0031-6989(88)80845-2.
PMID:3247358
Abstract
BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.
摘要
BN - 52021在“体外”可保护主动致敏的豚鼠心脏免受免疫反应影响。这种银杏内酯以剂量依赖方式减少介质释放（组胺、血栓素 - A2和过敏反应慢反应物质），尤其是组胺的释放。这些结果表明血小板活化因子在豚鼠过敏反应中起重要作用，或者BN - 52021具有更广泛的活性谱。
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