Koltai M, Lepran I, Szekeres L, Viossat I, Chabrier E, Braquet P
Eur J Pharmacol. 1986 Oct 14;130(1-2):133-6. doi: 10.1016/0014-2999(86)90192-5.
Hartley guinea-pigs were sensitized passively with antiovalbumin rabbit serum. Their isolated perfused hearts responded to the specific antigen with a marked decrease in contractile force, increase in perfusion pressure, and rhythm disturbances. All these impairments except tachycardia were decreased by BN 52021, a specific PAF-acether receptor antagonist, applied in a constant infusion before ovalbumin challenge. These findings suggest that PAF-acether plays a major role as mediator in cardiac anaphylaxis, and BN 52021 may be a valuable therapeutic agent in allergic conditions.
