Department of Neurology, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China.
Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China; Jilin Provincial Key Laboratory of Neuro-oncology, Jilin University, Changchun 130033, China.
Tissue Cell. 2020 Jun;64:101330. doi: 10.1016/j.tice.2020.101330. Epub 2020 Jan 10.
Mesenchymal stem cells (MSCs) are multipotent, genomic stable, self-renewable, and culturally expandable adult stem cells. MSCs facilitate tissue development, maintenance and repair, and produce secretory factors that support engraftment and trophic functions, marking them an attractive option in cell therapy, regenerative medicine and tissue engineering.
In this review, we summarize the recent researches regarding the isolation and characterization of MSCs, therapeutic applications and advanced engineering techniques. We also discuss the advantages and limitations that remain to be overcome for MSCs based therapy.
It has been demonstrated that MSCs are able to modulate endogenous tissue and immune cells. Preclinical studies and early phase clinical trials have shown their great potential for tissue engineering of bone, cartilage, marrow stroma, muscle, fat, and other connective tissues.
MSC-based therapy show considerable promise to rebuild damaged or diseased tissues, which could be a promising therapeutic method for regeneration medicine.
间充质干细胞（MSCs）是多能的、基因组稳定的、自我更新的、可文化扩增的成体干细胞。MSCs 促进组织发育、维持和修复，并产生支持植入和营养功能的分泌因子，这使它们成为细胞治疗、再生医学和组织工程的一个有吸引力的选择。
在这篇综述中，我们总结了关于 MSCs 的分离和鉴定、治疗应用和先进的工程技术的最新研究。我们还讨论了基于 MSCs 的治疗仍然需要克服的优点和局限性。
已经证明 MSCs 能够调节内源性组织和免疫细胞。临床前研究和早期临床试验表明，它们在骨、软骨、骨髓基质、肌肉、脂肪和其他结缔组织的组织工程中有很大的潜力。
基于 MSC 的治疗显示出相当大的重建受损或患病组织的潜力，这可能是再生医学的一种有前途的治疗方法。
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