Department of Internal Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan.
Department of Infectious Diseases, Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan.
Int J Mycobacteriol. 2020 Jan-Mar;9(1):76-82. doi: 10.4103/ijmy.ijmy_14_20.
Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony morphology in MABC lung disease.
This study aimed to test GPL core antigen in patients with MABC lung disease to investigate the relationship between coinfection/contamination in other nontuberculous mycobacteria species and colony morphology variant in MABC isolates. Patients with MABC lung disease and contamination diagnosed between 2012 and 2017 at our hospital were enrolled retrospectively.
Of the assessed patients, 43 patients with MABC lung disease and 13 with MABC contamination were included. There was a significant difference in anti-GPL-core IgA antibody levels between them (P = 0.02). Forty-three patients with MABC lung disease were divided into two groups as positive and negative antibodies groups. A significant increase in the positive anti-GPL-core IgA antibody was observed in coexistence with both Mycobacterium avium complex (MAC) (P = 0.02) and the isolate of the smooth variant (P = 0.03) in MABC.
Anti-GPL-core IgA antibodies in patients with MABC are greatly influenced by MAC coexistence, and colony morphology variant of the MABC isolate.
脓肿分枝杆菌复合体（MABC）在细胞壁上表现出光滑形态，表达糖脂肽聚糖（GPL），以及粗糙形态，表达减少的 GPL。很少有报道关注 MABC 肺部疾病中抗-GPL 核心免疫球蛋白 A（IgA）抗体与菌落形态之间的关系。
本研究旨在测试 MABC 肺部疾病患者中的 GPL 核心抗原，以研究其他非结核分枝杆菌物种的共感染/污染与 MABC 分离株菌落形态变异之间的关系。回顾性纳入 2012 年至 2017 年我院诊断为 MABC 肺部疾病和污染的患者。
评估的患者中，有 43 例 MABC 肺部疾病和 13 例 MABC 污染患者。他们的抗-GPL 核心 IgA 抗体水平有显著差异（P = 0.02）。43 例 MABC 肺部疾病患者分为阳性和阴性抗体组。在 MABC 中同时存在 MAC（P = 0.02）和光滑变体分离株时，观察到阳性抗-GPL 核心 IgA 抗体显著增加（P = 0.03）。
MABC 患者的抗-GPL 核心 IgA 抗体受 MAC 共存和 MABC 分离株菌落形态变异的影响很大。
