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J Vasc Interv Radiol. 2011 Feb;22(2):220-8. doi: 10.1016/j.jvir.2010.10.021.
To compare the in vivo distribution of the new embolic Embozene versus Embosphere as a control in the sheep renal and uterine vasculature.
Twelve sheep (three per group of product and size) were selectively embolized with Embozene 700 μm, Embozene 900 μm, Embosphere 500-700 μm, or Embosphere 700-900 μm, in one renal artery (0.5 mL microspheres) and in the two uterine arteries (0.25 mL each) and sacrificed 72 hours later for pathologic examination of kidney and uterus. Partition of microspheres in the vasculature was determined according to a classification of the renal and the uterine vasculatures into several zones. Vascular diameters and microsphere deformation were measured.
Embozene 700 μm and Embozene 900 μm occluded significantly more distally than Embosphere 500-700 μm and Embosphere 700-900 μm in renal and uterine vasculature. For Embozene, the vessel diameter was not significantly different between the two sizes, for each organ, whereas it was significantly larger for Embosphere 700-900 μm than for Embosphere 500-700 μm in each organ. Embozene deformation was significantly higher than that of Embosphere in renal and uterine vasculature, increased from proximal to distal in location for both organs and correlated negatively with vessel diameter (Rho = -0.623; P < .0001). Embosphere deformation did not vary according to the zone.
Embozene microspheres have a higher in vivo deformation, which results in a more distal occlusion within the vascular network compared with reference Embosphere microspheres. The diameter of occluded vessels varied for the tested size range for Embosphere but was independent of the tested microsphere size range used for Embozene. The deformation of Embozene appears to determine the size of the vessels occluded as opposed to the granulometric particle size, which makes level of occlusion unpredictable.
比较新型栓塞剂 Embozene 与对照 Embosphere 在绵羊肾和子宫血管中的体内分布。
将 12 只绵羊（每组产品和大小各 3 只）分别用 Embozene 700μm、Embozene 900μm、Embosphere 500-700μm 和 Embosphere 700-900μm 栓塞一侧肾动脉（0.5mL 微球）和两侧子宫动脉（各 0.25mL），72 小时后处死行肾和子宫的病理学检查。根据肾和子宫血管的分区将微球在血管中的分布进行分类，测量血管直径和微球变形。
Embozene 700μm 和 Embozene 900μm 在肾和子宫血管中的闭塞部位明显比 Embosphere 500-700μm 和 Embosphere 700-900μm 更靠远端。对于 Embozene，两种大小在每个器官中的血管直径无显著差异，而对于每个器官，Embosphere 700-900μm 的直径明显大于 Embosphere 500-700μm。Embozene 的变形显著高于 Embosphere，在肾和子宫血管中，从近端到远端的位置逐渐增加，与血管直径呈负相关（Rho=-0.623；P<.0001）。Embosphere 的变形不随分区而变化。
Embozene 微球具有更高的体内变形性，与对照 Embosphere 微球相比，导致在血管网络中更靠远端的闭塞。对于测试的粒径范围，Embosphere 闭塞血管的直径有所不同，但与 Embozene 测试的微球粒径范围无关。Embozene 的变形似乎决定了闭塞血管的大小，而不是颗粒大小，这使得闭塞程度不可预测。
