Faculty of Health Sciences, Centre of Reproduction, Development and Aging, Institute of Translational Medicine, University of Macau, Taipa, Macau SAR, China.
Department of Medicine, Jinan University, Guangzhou, China.
Med Res Rev. 2020 Nov;40(6):2089-2113. doi: 10.1002/med.21695. Epub 2020 May 31.
Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of cancer growth and metastasis. Recent evidence suggests that FOXO proteins are also involved in autophagy regulation. The relationship among FOXOs, autophagy, and cancer has been drawing attention of many who work in the field. This study summarizes the role of FOXO proteins and autophagy in cancer growth and metastasis and analyzes their potential roles in cancer disease management.
自噬是一种高度保守的细胞内降解过程，在细胞存活和应激反应以及癌症发展和转移中起着至关重要的作用。自噬过程涉及几个步骤，包括隔离、自噬体与溶酶体的融合以及降解。叉头框 O（FOXO）转录因子调节参与细胞代谢活性和癌症生长和转移信号通路的基因的表达。最近的证据表明，FOXO 蛋白也参与自噬的调节。FOXOs、自噬和癌症之间的关系引起了许多研究人员的关注。本研究总结了 FOXO 蛋白和自噬在癌症生长和转移中的作用，并分析了它们在癌症疾病管理中的潜在作用。
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