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慢性血栓栓塞性肺动脉高压与结节病之间的联系:是关联还是视觉上的伪装?

The link between chronic thromboembolic pulmonary hypertension and sarcoidosis: association or visual masquerade?

作者信息

Tandon Rajive, Baughman Robert P, Stanley Janice, Khan Ali A

机构信息

Rush University Medical Center, Chicago, IL, USA.

University of Cincinnati, Cincinnati, OH, USA.

出版信息

Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(4):352-355. doi: 10.36141/svdld.v34i4.5852. Epub 2017 Apr 28.

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) and sarcoidosis are recognized causes of pulmonary hypertension according to the World Health Organization classification scheme. This case series describes seven patients with sarcoidosis with a mean age of 61 who developed pulmonary hypertension. They were found to have CTEPH, diagnosed by either CT pulmonary angiography or a lung ventilation perfusion scan. They all underwent confirmatory right heart catheterization showing elevated mean pulmonary artery pressures (mean of 42 mmHg - normal less than 25 mmHg). Sarcoidosis has been previously shown to be associated with increased rates of venous thromboembolic disease. In these cases, patients with sarcoidosis later developed CTEPH and this may be another mechanism in which sarcoidosis can lead to pulmonary hypertension. .

摘要

根据世界卫生组织的分类方案,慢性血栓栓塞性肺动脉高压(CTEPH)和结节病是公认的肺动脉高压病因。本病例系列描述了7例结节病患者,平均年龄61岁,均出现了肺动脉高压。通过CT肺动脉造影或肺通气灌注扫描诊断,他们均被发现患有CTEPH。他们都接受了确诊性右心导管检查,结果显示平均肺动脉压升高(平均为42 mmHg,正常应低于25 mmHg)。先前已有研究表明,结节病与静脉血栓栓塞性疾病的发病率增加有关。在这些病例中,结节病患者后来发展为CTEPH,这可能是结节病导致肺动脉高压的另一种机制。

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