Bloem Ada E M, Veltkamp Marcel, Spruit Martijn A, Custers Jan W H, Bakker Eric W P, Dolk Hanneke M, Grutters Jan C
University of Applied Sciences Utrecht, Institute of Movement Studies, Faculty of Health Care, Utrecht, The Netherlands.
Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.
Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(4):317-326. doi: 10.36141/svdld.v35i4.7035. Epub 2020 Mar 9.
Patients with pulmonary fibrosis (PF) have a clear exercise intolerance. The 4-meter-gait-speed (4MGS) test and the 5-repetitions-sit-to-stand (5STS) test are easy, inexpensive and reliable measures of functional performance. Both tests have been validated in healthy adults and patients with chronic obstructive pulmonary disease. 4MGS test and 5STS test have not been studied in patients with PF. In this cross-sectional clinimetric validation study 51 PF patients conducted in random order the 4MGS test, 5STS test and the 6-min walk test (6MWT) on a single day. Additionally, body weight, height, lean body mass, health-related quality of life, disease severity, handgrip strength, dyspnoea and leg fatigue were assessed. The setting was a tertiary referral center for Interstitial Lung Diseases. Patients had a diagnosis of idiopathic pulmonary fibrosis (IPF, 37%), PF other than IPF (47%), or unclassified (16%). Patients walked 453±111m in six minutes. Moreover, it took the patients 2.0±0.5s to walk 4 m, and 12.0±3.8s for the 5STS test. The 4MGS test (r = 0.77; p<0.01) and the 5STS test (r = -0.41; p<0.01) correlated significantly with the distance walked in 6MWT. Indeed, 4MGS combined with handgrip strength and Medical Research Council dyspnoea grade could explain 75% of the variance in 6MWD. 4-meter-gait-speed and 5-repetitions sit-to-stand are significantly and independently correlated with the 6-minute walk distance in patients with pulmonary fibrosis. Indeed, 4-meter-gait-speed test may serve as a simple initial field test to assess exercise performance in patients with pulmonary fibrosis. .
肺纤维化（PF）患者存在明显的运动不耐受。4米步速（4MGS）测试和5次坐立试验（5STS）是评估功能表现的简便、经济且可靠的方法。这两项测试已在健康成年人和慢性阻塞性肺疾病患者中得到验证。4MGS测试和5STS测试尚未在PF患者中进行研究。在这项横断面临床测量学验证研究中，51名PF患者在同一天以随机顺序进行了4MGS测试、5STS测试和6分钟步行试验（6MWT）。此外，还评估了体重、身高、瘦体重、健康相关生活质量、疾病严重程度、握力、呼吸困难和腿部疲劳情况。研究地点为一家间质性肺病三级转诊中心。患者被诊断为特发性肺纤维化（IPF，37%）、非IPF的PF（47%）或未分类（16%）。患者在6分钟内行走了453±111米。此外，患者行走4米用时2.0±0.5秒，5STS测试用时12.0±3.8秒。4MGS测试（r = 0.77；p<0.01）和5STS测试（r = -0.41；p<0.01）与6MWT中的步行距离显著相关。实际上，4MGS结合握力和医学研究委员会呼吸困难分级可以解释6MWD中75%的差异。4米步速和5次坐立试验与肺纤维化患者的6分钟步行距离显著且独立相关。事实上，4米步速测试可作为一种简单的初始现场测试，用于评估肺纤维化患者的运动表现。
