Saha Biplab K, Burns Stacey L, Foulke Llewellyn A, Judson Marc A
Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, New York.
Division of Anesthesiology, Brigham and Women's Medical Center, Boston, Massachusetts.
Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(4):311-317. doi: 10.36141/svdld.v36i4.8667. Epub 2019 May 1.
Takayasu Arteritis (TAK) is a granulomatous large vessel vasculitis that predominantly affects the aorta, major aortic branches and pulmonary arteries resulting in pulselessness. Sarcoidosis is a systemic granulomatous disease of unknown etiology that can affect any organ. Numerous cases of coexistence of both these rare diseases have been described, suggesting that their association may be by more than chance alone.
To describe a case of coexistent TAK and sarcoidosis and review the world literature concerning this condition.
The clinical presentation and diagnostic approach is described of a woman with TAK who developed sarcoidosis. The world literature was reviewed by searching the PubMed and Google Scholar database for the terms 'Takayasu arteritis' and 'sarcoidosis'; 'Takayasu arteritis' and 'granuloma'; 'vasculitis' and 'sarcoidosis'; and 'vasculitis' and 'granuloma.' The identified individual articles were reviewed, and the bibliography of these articles were scrutinized to identify more cases. The pertinent clinical features of these cases were summarized.
A 36-year-old Caucasian woman, who was diagnosed with histologically confirmed TAK at 22 years of age, was referred for evaluation of mediastinal lymphadenopathy. The diagnosis of sarcoidosis was established on histopathology of a mediastinal lymph node biopsy. A literature review identified 23 additional cases of coexisting sarcoidosis and TAK, and the clinical features of these cases is described.
TAK and sarcoidosis may occur in the same patient. Given the prevalence of these diseases, concomitant development of these two diseases is unlikely to be by chance alone and probably reflects a unifying mechanism. Clinicians should be aware of this association in patients in order to make a timely diagnosis and optimize patient care.
高安动脉炎（TAK）是一种肉芽肿性大血管血管炎，主要累及主动脉、主动脉主要分支和肺动脉，导致无脉症。结节病是一种病因不明的全身性肉芽肿性疾病，可累及任何器官。已有许多这两种罕见疾病共存的病例报道，提示它们之间的关联可能并非偶然。
描述一例TAK与结节病共存的病例，并回顾有关这种情况的世界文献。
描述了一名患有TAK并发展为结节病的女性的临床表现和诊断方法。通过在PubMed和谷歌学术数据库中搜索“高安动脉炎”和“结节病”；“高安动脉炎”和“肉芽肿”；“血管炎”和“结节病”；以及“血管炎”和“肉芽肿”等术语来回顾世界文献。对识别出的单篇文章进行了综述，并仔细研究了这些文章的参考文献以确定更多病例。总结了这些病例的相关临床特征。
一名36岁的白种女性，22岁时经组织学确诊为TAK，因纵隔淋巴结肿大前来评估。纵隔淋巴结活检的组织病理学确诊为结节病。文献综述又发现了23例结节病与TAK共存的病例，并描述了这些病例的临床特征。
TAK和结节病可能发生在同一患者身上。鉴于这些疾病的患病率，这两种疾病同时发生不太可能仅是偶然，可能反映了一种统一的机制。临床医生应意识到患者中的这种关联，以便及时诊断并优化患者护理。
