Vaschetto Luis M, Ortiz Natalia
Instituto de Diversidad y Ecología Animal, Consejo Nacional de Investigaciones Científicas y Técnicas (IDEA, CONICET), Av. Vélez Sarsfield 299, X5000JJC Córdoba, Argentina.
Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, (FCEFyN, UNC), Av. Vélez Sarsfield 299, X5000JJC Córdoba, Argentina.
Curr Genomics. 2019 Sep;20(6):405-408. doi: 10.2174/1389202920666190320140721.
Sequence duplication is nowadays recognized as an important mechanism that underlies the evolution of eukaryote genomes, being indeed one of the most powerful strategies for the generation of adaptive diversity by modulating transcriptional activity. The evolutionary novelties simultaneously associated with sequence duplication and differential gene expression can be collectively referred to as duplication-mediated transcriptional regulation. In the last years, evidence has emerged supporting the idea that sequence duplication and functionalization represent important evolutionary strategies acting at the genome level, and both coding and non-coding sequences have been found to be targets of such events. Moreover, it has been proposed that deleterious effects of sequence duplication might be potentially silenced by endogenous cell machinery (, RNA interference, epigenetic repressive marks, ). Along these lines, our aim is to highlight the role of sequence duplication on transcriptional activity and the importance of both in genome evolution.
序列复制如今被认为是真核生物基因组进化的重要机制，实际上是通过调节转录活性产生适应性多样性的最强大策略之一。与序列复制和差异基因表达同时相关的进化新奇性可统称为复制介导的转录调控。近年来，有证据支持这样一种观点，即序列复制和功能化是在基因组水平起作用的重要进化策略，并且已发现编码序列和非编码序列都是此类事件的靶点。此外，有人提出序列复制的有害影响可能会被内源性细胞机制（如RNA干扰、表观遗传抑制标记）潜在地沉默。按照这些思路，我们的目标是强调序列复制对转录活性的作用以及两者在基因组进化中的重要性。
