[The importance of HLA antigens for the prognosis of the course and effect of treatment in systemic lupus erythematosus].

In the patients with systemic lupus erythematodes in comparison with the population controls an increased frequency of the following HLA antigens was found: A11, B7, B35, DR2 and DR3. A difference in the frequency of the various antigens of histocompatibility was found in the different variants of the disease. The relative risk of falling sick with lupus erythematodes increases with certain interallel and interlocus antigen combinations. The determination of the HLA antigens may be used in the practice for the institution of a proper treatment of the different variants of systemic lupus erythematodes.