Translational Medicine Research Center, MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.
Children's Research Institute, Gansu Provincial Cancer Hospital, Lanzhou, China.
Front Immunol. 2020 May 14;11:926. doi: 10.3389/fimmu.2020.00926. eCollection 2020.
The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies differ significantly between European and Asian populations. Here, we examined the association of rs3091244 with cancer risk in a Chinese population. rs3091244 was genotyped by Sanger sequencing in 4,971 cancer cases and 2,485 controls. The rs1205 and rs2794521 gene variants were also genotyped using TaqMan assays in subgroups. No association was detected between the genotyped CRP variants and cancer risk, with or without distinguishing cancer types, suggesting that circulating CRP is not causally involved in tumorigenesis in Chinese populations.
循环 C 反应蛋白（CRP）水平升高与癌症风险的关联已在欧洲人群中得到广泛研究；然而，结论存在争议。三等位 rs3091244 是一种功能验证的遗传变异，其等位基因频率在欧洲和亚洲人群中存在显著差异。在这里，我们在中国人群中研究了 rs3091244 与癌症风险的关联。rs3091244 通过 Sanger 测序在 4971 例癌症病例和 2485 例对照中进行了基因分型。rs1205 和 rs2794521 基因变异也使用 TaqMan 检测在亚组中进行了基因分型。未检测到 CRP 变体的基因型与癌症风险之间存在关联，无论是否区分癌症类型，这表明循环 CRP 在中国人群中与肿瘤发生没有因果关系。
