补体的新机制与功能
Novel mechanisms and functions of complement.
作者信息
Hajishengallis George, Reis Edimara S, Mastellos Dimitrios C, Ricklin Daniel, Lambris John D
机构信息
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
Nat Immunol. 2017 Nov 16;18(12):1288-1298. doi: 10.1038/ni.3858.
Abstract
Progress at the beginning of the 21st century transformed the perception of complement from that of a blood-based antimicrobial system to that of a global regulator of immunity and tissue homeostasis. More recent years have witnessed remarkable advances in structure-function insights and understanding of the mechanisms and locations of complement activation, which have added new layers of complexity to the biology of complement. This complexity is readily reflected by the multifaceted and contextual involvement of complement-driven networks in a wide range of inflammatory and neurodegenerative disorders and cancer. This Review provides an updated view of new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.
摘要
21世纪初的进展改变了人们对补体的认知，从基于血液的抗菌系统转变为免疫和组织稳态的全局调节因子。近年来，在补体结构与功能的认识、补体激活机制及部位的理解方面取得了显著进展，这为补体生物学增添了新的复杂层面。补体驱动网络在广泛的炎症、神经退行性疾病和癌症中的多方面及背景性参与，充分体现了这种复杂性。本综述提供了关于补体新的和先前未预料到的功能的最新观点，以及这些功能如何影响免疫和疾病发病机制。
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Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10948-10953. doi: 10.1073/pnas.1707364114. Epub 2017 Sep 26.
2
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