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用于局部捕获的声流控装置设计。

Design of acoustofluidic device for localized trapping.

作者信息

Li Li-Qiang, Jia Kun, Wu Er-Yong, Zhu Yong-Jian, Yang Ke-Ji

机构信息

State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, No. 38 Zheda Road, Hangzhou 310027, People's Republic of China.

State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi'an Jiaotong University, No. 28 West Xianning Road, 710049 Xi'an, People's Republic of China.

出版信息

Biomicrofluidics. 2020 May 21;14(3):034107. doi: 10.1063/5.0006649. eCollection 2020 May.

Abstract

State of the art acoustofluidics typically treat micro-particles in a multi-wavelength range due to the scale limitations of the established ultrasound field. Here, we report a spatial selective acoustofluidic device that allows trapping micro-particles and cells in a wavelength scale. A pair of interdigital transducers with a concentric-arc shape is used to compress the beam width, while pulsed actuation is adopted to localize the acoustic radiation force in the wave propagating direction. Unlike the traditional usage of geometrical focus, the proposed device is designed by properly superposing the convergent section of two focused surface acoustic waves. We successfully demonstrate a single-column alignment of 15-m polystyrene particles and double-column alignment of 8-m T cells in a wavelength scale. Through proof-of-concept experiments, the proposed acoustofluidic device shows potential applications in on-chip biological and chemical analyses, where localized handing is required.

摘要

由于现有超声场的尺度限制,当前先进的声流体技术通常在多波长范围内处理微颗粒。在此,我们报道一种空间选择性声流体装置,该装置能够在波长尺度上捕获微颗粒和细胞。一对具有同心弧形的叉指换能器用于压缩波束宽度,同时采用脉冲驱动使声辐射力在波传播方向上局部化。与传统的几何聚焦用法不同,所提出的装置是通过适当地叠加两个聚焦表面声波的会聚部分来设计的。我们成功地在波长尺度上演示了15微米聚苯乙烯颗粒的单列排列以及8微米T细胞的双列排列。通过概念验证实验,所提出的声流体装置在需要局部处理的片上生物和化学分析中显示出潜在的应用。

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本文引用的文献

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Acoustic tweezers for the life sciences.用于生命科学的声镊。
Nat Methods. 2018 Dec;15(12):1021-1028. doi: 10.1038/s41592-018-0222-9. Epub 2018 Nov 26.
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In-droplet microparticle separation using travelling surface acoustic wave.利用行波表面声波进行液滴内微粒分离
Biomicrofluidics. 2017 Dec 21;11(6):064112. doi: 10.1063/1.5010219. eCollection 2017 Nov.
6
Particle separation by phase modulated surface acoustic waves.通过相位调制表面声波进行粒子分离。
Biomicrofluidics. 2017 Oct 26;11(5):054115. doi: 10.1063/1.5001998. eCollection 2017 Sep.
7
Acoustic tweezers via sub-time-of-flight regime surface acoustic waves.基于亚渡越时间 regime 表面声波的声镊。
Sci Adv. 2016 Jul 13;2(7):e1600089. doi: 10.1126/sciadv.1600089. eCollection 2016 Jul.
10
A high-throughput acoustic cell sorter.一种高通量声学细胞分选仪。
Lab Chip. 2015 Oct 7;15(19):3870-3879. doi: 10.1039/c5lc00706b.

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