Bao Lingyu, Shi Bingyin, Shi Yun-Bo
1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, No.277, Yanta West Road, Xi'an, Shaanxi, 710061 People's Republic of China.
2Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892 USA.
Cell Biosci. 2020 May 19;10:66. doi: 10.1186/s13578-020-00429-9. eCollection 2020.
Organ homeostasis is essential for organ physiology and disease prevention. In adult vertebrates, the intestinal epithelium is maintained through constant cell proliferation in the crypt and apoptosis of differentiated epithelial cells, mainly at the tip of the villus. Based on studies with altered cell proliferation and tissue damage in the adult mouse intestine, we hypothesize that there is a communication between cell proliferation in the crypt and cell death on the villus, likely via cell-cell and cell-ECM (extracellular matrix) interactions, to coordinate the rate of cell proliferation and death, thus ensuring epithelial homeostasis.
器官稳态对于器官生理功能和疾病预防至关重要。在成年脊椎动物中，肠道上皮通过隐窝中持续的细胞增殖以及分化的上皮细胞（主要在绒毛顶端）的凋亡得以维持。基于对成年小鼠肠道中细胞增殖改变和组织损伤的研究，我们推测隐窝中的细胞增殖与绒毛上的细胞死亡之间存在一种通讯，可能是通过细胞 - 细胞和细胞 - 细胞外基质（ECM）相互作用，来协调细胞增殖和死亡的速率，从而确保上皮稳态。
