Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Pediatrics, The Barbara Davis Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J Nutr Sci. 2020 May 11;9:e16. doi: 10.1017/jns.2020.9. eCollection 2020.
We examined whether change in added sugar intake is associated with change in δC, a novel sugar biomarker, in thirty-nine children aged 5-10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δC in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake was associated with change in the δC biomarker, where for every 1-g increase in added sugar intake between the two time points, there was an increase in δC of 0⋅0082 ( = 0⋅0053), independent of change in HbA1c and δN. The δC biomarker may be used as a measure of compliance in an intervention study of children under the age of 10 years who are at increased risk for type 1 diabetes, in which the goal was to reduce dietary sugar intake.
我们研究了在科罗拉多州（美国）的一个儿童 1 型糖尿病高危前瞻性队列中，39 名 5-10 岁儿童中，添加糖摄入量的变化是否与 δC（一种新型糖生物标志物）的变化有关。通过两次 FFQ 报告添加糖摄入量和红细胞 δC，两次时间点之间的中位数间隔为 2 年。添加糖摄入量的变化与 δC 生物标志物的变化相关，在两次时间点之间，添加糖摄入量每增加 1 克，δC 就会增加 0.0082（=0.0053），与 HbA1c 和 δN 的变化无关。在针对高危儿童 1 型糖尿病的干预研究中，δC 生物标志物可用于衡量儿童对减少饮食中糖摄入量的依从性，这些儿童的年龄均小于 10 岁。
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