Trivedi Amar, Arora Rishi
Department of Cardiology, Northwestern Memorial Hospital, Chicago, IL, USA.
J Innov Card Rhythm Manag. 2018 Dec 15;9(12):3440-3445. doi: 10.19102/icrm.2018.091204. eCollection 2018 Dec.
In this review, we examine the current state of gene therapy for the treatment of cardiac arrhythmias. We describe advances and challenges in successfully creating and incorporating gene vectors into the myocardium. After summarizing the current scientific research in gene transfer technology, we then focus on the most promising areas of gene therapy at this time, which is the treatment of atrial fibrillation and ventricular tachyarrhythmias. We also review the scientific literature to determine how gene therapy could potentially be used to treat patients with cardiac arrhythmias.
在本综述中，我们探讨了用于治疗心律失常的基因疗法的现状。我们描述了成功创建基因载体并将其整合到心肌中的进展与挑战。在总结了基因转移技术的当前科学研究之后，我们接着聚焦于目前基因疗法最具前景的领域，即心房颤动和室性快速心律失常的治疗。我们还查阅了科学文献，以确定基因疗法如何法如何可能用于治疗心律失常患者。
