Zelis Jo M, van 't Veer Marcel, Houterman Saskia, Pijls Nico H J, Tonino Pim A L
Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands.
Netherlands Heart Registration, Utrecht, the Netherlands.
Int J Cardiol Heart Vasc. 2020 May 22;28:100536. doi: 10.1016/j.ijcha.2020.100536. eCollection 2020 Jun.
Little is known about survival and quality of life (QoL) of patients treated by transcatheter aortic valve implantation (TAVI) compared to the age- and sex-matched general population. In this study we compared subgroups of the National Heart Registration TAVI cohort to the Dutch age- and sex-matched population at the level of survival and QoL.
From the Netherlands Heart Registration (NHR) the TAVI cohort (5489 patients, period 2013-2017) was extracted. These data were compared to the national Dutch population data collected from the national statistics office, Statistics Netherlands (CBS). Subgroups were defined according to sex and age (<65, 65-80 and >80). For QoL analyses the age subgroups <65, 65-75 and >75 were used. Long term survival was significantly higher in the general population compared to the TAVI population. Elderly TAVI patients (>80 years) had the same survival as the age-matched general population (46vs43% at 5 years, respectively). Survival in women was better than in men in both the general population and the TAVI cohort. Patients treated by TAVI, aged 65 years and older had a comparable QoL to that of the general population.
This study shows that TAVI patients aged 80 years and older have a similar long-term survival as an age-matched general population. However, because of lower survival in under 80 TAVI patients, the overall long term survival of all TAVI patients is worse than that of the general population in the Netherlands. This study also suggests that QoL after TAVI treatment is comparable to QoL in the general population.
与年龄和性别匹配的普通人群相比，经导管主动脉瓣植入术（TAVI）治疗患者的生存率和生活质量（QoL）鲜为人知。在本研究中，我们在生存和生活质量水平上，将国家心脏注册TAVI队列的亚组与荷兰年龄和性别匹配的人群进行了比较。
从荷兰心脏注册（NHR）中提取了TAVI队列（5489例患者，2013 - 2017年）。这些数据与从荷兰国家统计局（CBS）收集的荷兰全国人口数据进行了比较。亚组根据性别和年龄（<65岁、65 - 80岁和>80岁）定义。对于生活质量分析，使用了<65岁、65 - 75岁和>75岁的年龄亚组。普通人群的长期生存率显著高于TAVI人群。老年TAVI患者（>80岁）的生存率与年龄匹配的普通人群相同（5年时分别为46%对43%）。在普通人群和TAVI队列中，女性的生存率均高于男性。65岁及以上接受TAVI治疗的患者的生活质量与普通人群相当。
本研究表明，80岁及以上的TAVI患者与年龄匹配的普通人群具有相似的长期生存率。然而，由于80岁以下TAVI患者的生存率较低，所有TAVI患者的总体长期生存率低于荷兰普通人群。本研究还表明，TAVI治疗后的生活质量与普通人群相当。
