Cupédo R N, De Weerd H
Department of Anatomy and Embryology, University of Groningen, Netherlands.
Acta Morphol Neerl Scand. 1988;26(1):19-31.
Following intraventricular injection of 5,7-dihydroxytryptamine in rats and survival periods up to 25 weeks, the supraependymal serotonergic axon plexus in the lateral and fourth ventricle, except for the plexus upon the hippocampal fimbria in some cases, showed no evidence of regenerative capacities. This contrasts with many reports on regeneration of intraparenchymal serotonergic fibre systems in the mammalian brain following mechanical or neurotoxin-induced experimental degeneration. The supraependymal plexus appears to be critically involved in maintainance of normal ependymal integrity in that following its experimentally induced death many ependymal cells exhibit various pathological alterations in all regions examined. Degeneration of this plexus is also associated with heavy phagocytotic reactions. Morphology, distribution and possible origins of supraependymal macrophages are briefly discussed.
给大鼠脑室内注射5,7 - 二羟基色胺并使其存活25周后，侧脑室和第四脑室内的室管膜上5-羟色胺能轴突丛，除了某些情况下海马伞上的丛外，未显示出再生能力的迹象。这与许多关于哺乳动物脑实质内5-羟色胺能纤维系统在机械性或神经毒素诱导的实验性变性后再生的报道形成对比。室管膜上丛似乎在维持正常室管膜完整性方面起着关键作用，因为在实验诱导其死亡后，在所检查的所有区域中许多室管膜细胞都表现出各种病理改变。该丛的变性还与强烈的吞噬反应有关。文中简要讨论了室管膜上巨噬细胞的形态、分布及可能的来源。
